Non-coding structural variation differentially impacts attention-deficit hyperactivity disorder (ADHD) gene networks in African American vs Caucasian children

• Published in: Scientific reports Vol. 10; no. 1; p. 15252
• Main Authors: Liu, Yichuan, Chang, Xiao, Qu, Huiqi, Glessner, Joseph, Tian, Lifeng, Li, Dong, Qiu, Haijun, Sleiman, Patrick M. A., Hakonarson, Hakon
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.09.2020
• Subjects: 631/208/212; 631/208/457; 631/208/737; 631/378; 631/61/514/2254; African Americans - genetics; Attention Deficit Disorder with Hyperactivity - ethnology; Attention Deficit Disorder with Hyperactivity - genetics; Case-Control Studies; Child; European Continental Ancestry Group - genetics; Female; Gene Regulatory Networks; Genetic Predisposition to Disease; Genetic Variation; Humanities and Social Sciences; Humans; Male; multidisciplinary; RNA, Untranslated - genetics; Science; Science (multidisciplinary); Whole Genome Sequencing

Previous studies of attention-deficit hyperactivity disorder (ADHD) have suggested that structural variants (SVs) play an important role but these were mainly studied in subjects of European ancestry and focused on coding regions. In this study, we sought to address the role of SVs in non-European p...