Age-related decline in executive function as a hallmark of cognitive ageing in primates: an overview of cognitive and neurobiological studies

Executive function (EF) is a complex construct that reflects multiple higher-order cognitive processes such as planning, updating, inhibiting and set-shifting. Decline in these functions is a hallmark of cognitive ageing in humans, and age differences and changes in EF correlate with age-related dif...

Full description

Saved in:
Bibliographic Details
Published inPhilosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 375; no. 1811; p. 20190618
Main Authors Lacreuse, Agnès, Raz, Naftali, Schmidtke, Daniel, Hopkins, William D., Herndon, James G.
Format Journal Article
LanguageEnglish
Published The Royal Society 09.11.2020
Subjects
Review
Online AccessGet full text

Cover

Abstract Executive function (EF) is a complex construct that reflects multiple higher-order cognitive processes such as planning, updating, inhibiting and set-shifting. Decline in these functions is a hallmark of cognitive ageing in humans, and age differences and changes in EF correlate with age-related differences and changes in association cortices, particularly the prefrontal areas. Here, we review evidence for age-related decline in EF and associated neurobiological changes in prosimians, New World and Old World monkeys, apes and humans. While EF declines with age in all primate species studied, the relationship of this decline with age-related alterations in the prefrontal cortex remains unclear, owing to the scarcity of neurobiological studies focusing on the ageing brain in most primate species. In addition, the influence of sex, vascular and metabolic risk, and hormonal status has rarely been considered. We outline several methodological limitations and challenges with the goal of producing a comprehensive integration of cognitive and neurobiological data across species and elucidating how ageing shapes neurocognitive trajectories in primates with different life histories, lifespans and brain architectures. Such comparative investigations are critical for fostering translational research and understanding healthy and pathological ageing in our own species. This article is part of the theme issue ‘Evolution of the primate ageing process’.
AbstractList Executive function (EF) is a complex construct that reflects multiple higher-order cognitive processes such as planning, updating, inhibiting and set-shifting. Decline in these functions is a hallmark of cognitive ageing in humans, and age differences and changes in EF correlate with age-related differences and changes in association cortices, particularly the prefrontal areas. Here, we review evidence for age-related decline in EF and associated neurobiological changes in prosimians, New World and Old World monkeys, apes and humans. While EF declines with age in all primate species studied, the relationship of this decline with age-related alterations in the prefrontal cortex remains unclear, owing to the scarcity of neurobiological studies focusing on the ageing brain in most primate species. In addition, the influence of sex, vascular and metabolic risk, and hormonal status has rarely been considered. We outline several methodological limitations and challenges with the goal of producing a comprehensive integration of cognitive and neurobiological data across species and elucidating how ageing shapes neurocognitive trajectories in primates with different life histories, lifespans and brain architectures. Such comparative investigations are critical for fostering translational research and understanding healthy and pathological ageing in our own species. This article is part of the theme issue ‘Evolution of the primate ageing process’.
Executive function (EF) is a complex construct that reflects multiple higher-order cognitive processes such as planning, updating, inhibiting and set-shifting. Decline in these functions is a hallmark of cognitive ageing in humans, and age differences and changes in EF correlate with age-related differences and changes in association cortices, particularly the prefrontal areas. Here, we review evidence for age-related decline in EF and associated neurobiological changes in prosimians, New World and Old World monkeys, apes and humans. While EF declines with age in all primate species studied, the relationship of this decline with age-related alterations in the prefrontal cortex remains unclear, owing to the scarcity of neurobiological studies focusing on the ageing brain in most primate species. In addition, the influence of sex, vascular and metabolic risk, and hormonal status has rarely been considered. We outline several methodological limitations and challenges with the goal of producing a comprehensive integration of cognitive and neurobiological data across species and elucidating how ageing shapes neurocognitive trajectories in primates with different life histories, lifespans and brain architectures. Such comparative investigations are critical for fostering translational research and understanding healthy and pathological ageing in our own species. This article is part of the theme issue 'Evolution of the primate ageing process'.Executive function (EF) is a complex construct that reflects multiple higher-order cognitive processes such as planning, updating, inhibiting and set-shifting. Decline in these functions is a hallmark of cognitive ageing in humans, and age differences and changes in EF correlate with age-related differences and changes in association cortices, particularly the prefrontal areas. Here, we review evidence for age-related decline in EF and associated neurobiological changes in prosimians, New World and Old World monkeys, apes and humans. While EF declines with age in all primate species studied, the relationship of this decline with age-related alterations in the prefrontal cortex remains unclear, owing to the scarcity of neurobiological studies focusing on the ageing brain in most primate species. In addition, the influence of sex, vascular and metabolic risk, and hormonal status has rarely been considered. We outline several methodological limitations and challenges with the goal of producing a comprehensive integration of cognitive and neurobiological data across species and elucidating how ageing shapes neurocognitive trajectories in primates with different life histories, lifespans and brain architectures. Such comparative investigations are critical for fostering translational research and understanding healthy and pathological ageing in our own species. This article is part of the theme issue 'Evolution of the primate ageing process'.
Author Raz, Naftali
Schmidtke, Daniel
Lacreuse, Agnès
Herndon, James G.
Hopkins, William D.
AuthorAffiliation 3 Max Planck Institute for Human Development , Berlin , Germany
4 University of Veterinary Medicine, Foundation , Hannover , Germany
6 Department of Psychology, Emory University , Atlanta, GA , USA
1 Psychological and Brain Sciences, University of Massachusetts , Tobin Hall, 135 Hicks Way, Amherst, MA 01003 , USA
2 Department of Psychology, Wayne State University , Detroit, MI , USA
5 Keeling Center for Comparative Medicine and Research, University of Texas, MD Anderson Cancer Center, Bastrop, TX, USA
AuthorAffiliation_xml – name: 1 Psychological and Brain Sciences, University of Massachusetts , Tobin Hall, 135 Hicks Way, Amherst, MA 01003 , USA
– name: 6 Department of Psychology, Emory University , Atlanta, GA , USA
– name: 2 Department of Psychology, Wayne State University , Detroit, MI , USA
– name: 3 Max Planck Institute for Human Development , Berlin , Germany
– name: 4 University of Veterinary Medicine, Foundation , Hannover , Germany
– name: 5 Keeling Center for Comparative Medicine and Research, University of Texas, MD Anderson Cancer Center, Bastrop, TX, USA
Author_xml – sequence: 1
  givenname: Agnès
  orcidid: 0000-0003-2890-9649
  surname: Lacreuse
  fullname: Lacreuse, Agnès
  organization: Psychological and Brain Sciences, University of Massachusetts, Tobin Hall, 135 Hicks Way, Amherst, MA 01003, USA
– sequence: 2
  givenname: Naftali
  surname: Raz
  fullname: Raz, Naftali
  organization: Department of Psychology, Wayne State University, Detroit, MI, USA, Max Planck Institute for Human Development, Berlin, Germany
– sequence: 3
  givenname: Daniel
  orcidid: 0000-0002-3154-7135
  surname: Schmidtke
  fullname: Schmidtke, Daniel
  organization: University of Veterinary Medicine, Foundation, Hannover, Germany
– sequence: 4
  givenname: William D.
  surname: Hopkins
  fullname: Hopkins, William D.
  organization: Keeling Center for Comparative Medicine and Research, University of Texas, MD Anderson Cancer Center, Bastrop, TX, USA
– sequence: 5
  givenname: James G.
  surname: Herndon
  fullname: Herndon, James G.
  organization: Department of Psychology, Emory University, Atlanta, GA, USA
BookMark eNp1kUFP3DAQha0KVBbotWcfe8liO04c91AJodIiIXGBs-U446xbr01tZyk_gv9MAvTQlTjNYd779GbeMToIMQBCnylZUyK7s5RLv2aEyjVpafcBrSgXtGJSkAO0IrJlVcfr9ggd5_yLECIbwT-io5rJhja8XqGn8xGqBF4XGPAAxrsA2AUMf8FMxe0A2ymY4mLAOmONN9r7rU6_cbTYxDG4F40ewYVx8d0nt51Z-SvWAccdpJ2Dhz1xGHCAKcXeRR9HZ7THuUyDg3yKDq32GT69zRN0d_n99uJndX3z4-ri_LoynLelEk3dCNl2YKkBYCBta6GlhMN8ccMHyxjpBGWit31LLR-oldwSYYBZzoDWJ-jbK_d-6rcwGAglaa9ewqdHFbVT_2-C26gx7pRo-PLDGfDlDZDinwlyUVuXDXivA8QpK8bnoIQ1tZyl_FVqUsw5gVXGFb18dCY7ryhRS5NqaVItTaqlydm23rP9S_eO4RnwbqYU
CitedBy_id crossref_primary_10_1016_j_neubiorev_2023_105422
crossref_primary_10_1016_j_neurobiolaging_2022_12_001
crossref_primary_10_1186_s12877_024_04714_x
crossref_primary_10_1002_ajp_23264
crossref_primary_10_1016_j_ijpsycho_2023_112295
crossref_primary_10_3389_fnagi_2024_1350239
crossref_primary_10_1159_000531193
crossref_primary_10_3389_fnins_2023_1158141
crossref_primary_10_1002_trc2_12284
crossref_primary_10_1002_ajp_23260
crossref_primary_10_3390_healthcare12161663
crossref_primary_10_1016_j_anbehav_2024_02_018
crossref_primary_10_1016_j_bbr_2020_113053
crossref_primary_10_1007_s11065_023_09584_5
crossref_primary_10_1016_j_neurobiolaging_2025_03_010
crossref_primary_10_1038_s44159_024_00341_w
crossref_primary_10_3390_biom14121621
crossref_primary_10_3233_JAD_230066
crossref_primary_10_1007_s11357_024_01188_y
crossref_primary_10_3758_s13423_024_02457_9
crossref_primary_10_1111_2041_210X_14181
crossref_primary_10_3390_vaccines9040388
crossref_primary_10_1002_evan_22054
crossref_primary_10_1002_alz_14453
crossref_primary_10_1016_j_neurobiolaging_2023_08_009
crossref_primary_10_3389_fpsyg_2022_987203
crossref_primary_10_5812_ans_129428
crossref_primary_10_3390_ani13172702
crossref_primary_10_1016_j_neuropharm_2024_110114
crossref_primary_10_1186_s12877_024_04739_2
crossref_primary_10_1002_ajp_23337
crossref_primary_10_1111_psyg_13241
crossref_primary_10_3390_nu15173770
crossref_primary_10_1002_ajp_23214
crossref_primary_10_1016_j_neuroimage_2025_121038
crossref_primary_10_1016_j_neurobiolaging_2023_02_008
crossref_primary_10_1016_j_physbeh_2024_114579
crossref_primary_10_23736_S0022_4707_24_15618_6
crossref_primary_10_1016_j_neubiorev_2023_105294
crossref_primary_10_31083_j_jin2104122
crossref_primary_10_1038_s41598_022_09939_7
crossref_primary_10_1146_annurev_psych_022024_103901
crossref_primary_10_1098_rstb_2019_0605
crossref_primary_10_1016_j_ynirp_2021_100054
crossref_primary_10_24072_pcjournal_33
crossref_primary_10_1212_WNL_0000000000207854
crossref_primary_10_1002_ajp_23250
crossref_primary_10_3389_fpubh_2022_1035521
crossref_primary_10_3758_s13428_023_02104_6
crossref_primary_10_3389_fpsyg_2022_1047242
crossref_primary_10_1007_s40495_023_00337_9
crossref_primary_10_1093_lifemedi_lnad017
Cites_doi 10.1073/pnas.0708228104
10.1073/pnas.1016709108
10.1016/j.neuroimage.2011.02.075
10.1073/pnas.1919895116
10.1523/JNEUROSCI.09-10-03568.1989
10.1002/ajp.22949
10.1007/BF02381394
10.1007/s10329-019-00755-8
10.1093/cercor/bhi044
10.1006/exnr.1999.7192
10.3389/fpsyg.2013.00012
10.1093/geronj/34.2.209
10.1093/brain/122.5.963
10.1016/j.cub.2014.05.076
10.3390/brainsci7050049
10.1016/j.yhbeh.2015.03.001
10.1126/science.1146282
10.1037/a0014283
10.1007/s11357-011-9278-5
10.1016/j.neurobiolaging.2020.02.027
10.1016/j.neurobiolaging.2005.08.004
10.1146/annurev-psych-113011-143750
10.1016/B978-0-12-804042-3.00093-2
10.1038/nature08090
10.1016/j.neurobiolaging.2013.03.028
10.1016/j.neuroscience.2014.05.008
10.3389/fnagi.2014.00082
10.1016/j.exger.2006.09.013
10.1016/j.neuron.2016.10.018
10.3389/fnagi.2016.00315
10.1002/dneu.22483
10.1037/0735-7044.119.1.118
10.1002/cne.10099
10.3389/fnagi.2012.00031
10.1016/B978-1-4832-2821-1.50012-4
10.1007/s004010100429
10.1016/j.neuroimage.2014.06.053
10.1016/j.neurobiolaging.2016.12.022
10.1016/j.jalz.2018.06.3057
10.1016/j.bbr.2004.12.003
10.1016/j.neurobiolaging.2007.03.022
10.1016/B978-012369391-4/50039-4
10.1016/j.neurobiolaging.2009.05.018
10.1016/j.neuroimage.2006.01.021
10.1016/0197-4580(93)90055-G
10.1016/0197-4580(93)90050-L
10.1016/j.neurobiolaging.2018.08.018
10.1016/B978-0-12-811829-0.00021-2
10.1016/j.neurobiolaging.2013.08.036
10.1093/geronj/16.4.381
10.1098/rspb.2014.0830
10.1016/j.neures.2017.06.002
10.1016/S0197-4580(99)00097-4
10.1016/j.tics.2013.09.013
10.3389/fnbeh.2014.00446
10.1001/archneur.56.3.338
10.1093/ilar.52.1.54
10.1016/j.neuroimage.2011.11.050
10.1212/WNL.57.4.632
10.1523/ENEURO.0154-19.2019
10.1037/0882-7974.19.3.482
10.1016/S0166-4328(96)02256-5
10.1016/S0197-4580(02)00054-4
10.1093/cercor/8.4.295
10.1016/0197-4580(92)90016-Q
10.1007/PL00005665
10.1371/journal.pone.0109393
10.1093/oso/9780195106237.001.0001
10.1007/s10522-012-9388-1
10.1037/h0054182
10.1038/nature10243
10.1002/hbm.20129
10.1001/archneur.1963.00460070100010
10.1006/cogp.1999.0734
10.1016/j.neuropsychologia.2009.01.003
10.1017/S1355617717000704
10.1037/0882-7974.7.4.571
10.1016/j.neuroscience.2012.09.077
10.1016/j.neuroimage.2018.10.010
10.1016/S0378-5955(98)00201-9
10.1093/ilar.38.3.142
10.1016/j.neurobiolaging.2010.09.009
10.1098/rstb.2013.0483
10.1037/0735-7044.116.3.387
10.1016/j.cortex.2016.04.023
10.1002/hbm.20128
10.1523/JNEUROSCI.1852-07.2008
10.1007/BF03393227
10.1016/0197-4580(95)02014-4
10.1016/j.neurobiolaging.2018.10.003
10.1037/0033-2909.120.2.272
10.1016/S0197-4580(00)00098-1
10.1016/j.neubiorev.2014.02.005
10.1016/B978-012351830-9/50028-7
10.1002/ajp.22924
10.1016/j.dib.2018.10.067
10.1111/j.1365-3040.2009.01929.x
10.1016/B978-0-12-564340-5.50019-6
10.1002/ajp.22281
10.1016/j.anbehav.2015.01.002
ContentType Journal Article
Copyright 2020 The Author(s) 2020
Copyright_xml – notice: 2020 The Author(s) 2020
DBID AAYXX
CITATION
7X8
5PM
DOI 10.1098/rstb.2019.0618
DatabaseName CrossRef
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE - Academic
DatabaseTitleList CrossRef
MEDLINE - Academic
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Sciences (General)
Biology
DocumentTitleAlternate Aging of executive function in primates
EISSN 1471-2970
ExternalDocumentID PMC7540957
10_1098_rstb_2019_0618
GrantInformation_xml – fundername: ;
  grantid: R01- AG046266; NS-42867; P01-AG02642; P51OD011132.; P51RR000165; R01-AG011230; U42-OD-011197.
GroupedDBID ---
-~X
0R~
29O
2WC
4.4
53G
AACGO
AANCE
AAYXX
ABBHK
ABPLY
ABTLG
ABXSQ
ACPRK
ACSFO
ADBBV
AEUPB
AEXZC
AFRAH
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
CITATION
DCCCD
DIK
E3Z
EBS
F5P
GX1
H13
HYE
HZ~
IPSME
JAAYA
JBMMH
JENOY
JHFFW
JKQEH
JLS
JLXEF
JPM
JSG
JST
KQ8
MRS
MV1
NSAHA
O9-
OK1
RPM
RRY
SA0
TN5
V1E
W8F
YNT
~02
7X8
5PM
ID FETCH-LOGICAL-c446t-75357968ef1cee2e9f6fe6104e09654df22087127bfb61f4d1f94f07ce2f42e13
ISSN 0962-8436
1471-2970
IngestDate Thu Aug 21 18:27:38 EDT 2025
Fri Jul 11 02:16:53 EDT 2025
Tue Jul 01 03:25:32 EDT 2025
Thu Apr 24 23:09:14 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1811
Language English
License Published by the Royal Society. All rights reserved.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c446t-75357968ef1cee2e9f6fe6104e09654df22087127bfb61f4d1f94f07ce2f42e13
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
One contribution of 16 to a theme issue ‘Evolution of the primate ageing process’.
All authors have contributed equally.
ORCID 0000-0002-3154-7135
0000-0003-2890-9649
OpenAccessLink https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2019.0618
PMID 32951543
PQID 2444602539
PQPubID 23479
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7540957
proquest_miscellaneous_2444602539
crossref_citationtrail_10_1098_rstb_2019_0618
crossref_primary_10_1098_rstb_2019_0618
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-11-09
PublicationDateYYYYMMDD 2020-11-09
PublicationDate_xml – month: 11
  year: 2020
  text: 2020-11-09
  day: 09
PublicationDecade 2020
PublicationTitle Philosophical transactions of the Royal Society of London. Series B. Biological sciences
PublicationYear 2020
Publisher The Royal Society
Publisher_xml – name: The Royal Society
References e_1_3_7_83_2
e_1_3_7_60_2
e_1_3_7_87_2
e_1_3_7_22_2
e_1_3_7_41_2
e_1_3_7_64_2
Luria AR (e_1_3_7_13_2) 1966
e_1_3_7_26_2
e_1_3_7_45_2
e_1_3_7_49_2
e_1_3_7_103_2
e_1_3_7_107_2
e_1_3_7_91_2
e_1_3_7_72_2
e_1_3_7_99_2
e_1_3_7_30_2
e_1_3_7_76_2
e_1_3_7_11_2
e_1_3_7_53_2
e_1_3_7_95_2
e_1_3_7_15_2
e_1_3_7_57_2
e_1_3_7_38_2
e_1_3_7_19_2
e_1_3_7_4_2
e_1_3_7_111_2
e_1_3_7_8_2
Delacourte A (e_1_3_7_66_2) 1995; 318
e_1_3_7_80_2
e_1_3_7_61_2
e_1_3_7_84_2
Lacreuse A (e_1_3_7_37_2) 2009
e_1_3_7_65_2
e_1_3_7_88_2
e_1_3_7_42_2
Picq JL (e_1_3_7_74_2) 1995; 7
e_1_3_7_23_2
e_1_3_7_69_2
e_1_3_7_46_2
e_1_3_7_27_2
e_1_3_7_102_2
e_1_3_7_106_2
e_1_3_7_9_2
e_1_3_7_50_2
e_1_3_7_73_2
e_1_3_7_96_2
e_1_3_7_31_2
e_1_3_7_54_2
e_1_3_7_77_2
e_1_3_7_92_2
e_1_3_7_12_2
e_1_3_7_35_2
e_1_3_7_58_2
Tomasello M (e_1_3_7_100_2) 1997
e_1_3_7_16_2
e_1_3_7_39_2
e_1_3_7_110_2
e_1_3_7_5_2
e_1_3_7_109_2
e_1_3_7_62_2
e_1_3_7_81_2
e_1_3_7_20_2
e_1_3_7_43_2
e_1_3_7_85_2
e_1_3_7_24_2
e_1_3_7_47_2
Bons N (e_1_3_7_68_2) 2006; 5
e_1_3_7_89_2
e_1_3_7_28_2
Herndon JG (e_1_3_7_36_2) 2002
e_1_3_7_101_2
e_1_3_7_105_2
e_1_3_7_51_2
e_1_3_7_97_2
e_1_3_7_70_2
e_1_3_7_55_2
e_1_3_7_93_2
e_1_3_7_32_2
e_1_3_7_59_2
e_1_3_7_78_2
e_1_3_7_17_2
e_1_3_7_2_2
Jacobsen CF (e_1_3_7_34_2) 1936; 13
Goldstein S (e_1_3_7_6_2) 2013
e_1_3_7_108_2
Teuber HL (e_1_3_7_14_2) 1972; 32
e_1_3_7_40_2
e_1_3_7_82_2
e_1_3_7_44_2
e_1_3_7_63_2
e_1_3_7_86_2
e_1_3_7_21_2
e_1_3_7_48_2
e_1_3_7_25_2
e_1_3_7_67_2
e_1_3_7_29_2
e_1_3_7_104_2
e_1_3_7_90_2
e_1_3_7_71_2
e_1_3_7_98_2
e_1_3_7_10_2
e_1_3_7_33_2
e_1_3_7_52_2
e_1_3_7_75_2
e_1_3_7_94_2
e_1_3_7_56_2
e_1_3_7_79_2
e_1_3_7_18_2
e_1_3_7_112_2
e_1_3_7_3_2
e_1_3_7_7_2
References_xml – start-page: 29
  volume-title: Animal models of human cognitive aging. Aging medicine
  year: 2009
  ident: e_1_3_7_37_2
– ident: e_1_3_7_83_2
  doi: 10.1073/pnas.0708228104
– ident: e_1_3_7_108_2
  doi: 10.1073/pnas.1016709108
– ident: e_1_3_7_96_2
  doi: 10.1016/j.neuroimage.2011.02.075
– ident: e_1_3_7_31_2
  doi: 10.1073/pnas.1919895116
– ident: e_1_3_7_46_2
  doi: 10.1523/JNEUROSCI.09-10-03568.1989
– ident: e_1_3_7_97_2
  doi: 10.1002/ajp.22949
– ident: e_1_3_7_67_2
  doi: 10.1007/BF02381394
– ident: e_1_3_7_98_2
  doi: 10.1007/s10329-019-00755-8
– ident: e_1_3_7_23_2
  doi: 10.1093/cercor/bhi044
– ident: e_1_3_7_56_2
  doi: 10.1006/exnr.1999.7192
– ident: e_1_3_7_20_2
  doi: 10.3389/fpsyg.2013.00012
– start-page: 178
  volume-title: Aging in nonhuman primates. Interdisciplinary topics in gerontology
  year: 2002
  ident: e_1_3_7_36_2
– ident: e_1_3_7_45_2
  doi: 10.1093/geronj/34.2.209
– ident: e_1_3_7_28_2
  doi: 10.1093/brain/122.5.963
– ident: e_1_3_7_105_2
  doi: 10.1016/j.cub.2014.05.076
– ident: e_1_3_7_35_2
  doi: 10.3390/brainsci7050049
– ident: e_1_3_7_62_2
  doi: 10.1016/j.yhbeh.2015.03.001
– ident: e_1_3_7_104_2
  doi: 10.1126/science.1146282
– ident: e_1_3_7_112_2
  doi: 10.1037/a0014283
– ident: e_1_3_7_42_2
  doi: 10.1007/s11357-011-9278-5
– ident: e_1_3_7_78_2
  doi: 10.1016/j.neurobiolaging.2020.02.027
– ident: e_1_3_7_50_2
  doi: 10.1016/j.neurobiolaging.2005.08.004
– ident: e_1_3_7_9_2
  doi: 10.1146/annurev-psych-113011-143750
– ident: e_1_3_7_4_2
  doi: 10.1016/B978-0-12-804042-3.00093-2
– ident: e_1_3_7_92_2
  doi: 10.1038/nature08090
– ident: e_1_3_7_109_2
  doi: 10.1016/j.neurobiolaging.2013.03.028
– ident: e_1_3_7_58_2
  doi: 10.1016/j.neuroscience.2014.05.008
– ident: e_1_3_7_79_2
  doi: 10.3389/fnagi.2014.00082
– ident: e_1_3_7_71_2
  doi: 10.1016/j.exger.2006.09.013
– ident: e_1_3_7_93_2
  doi: 10.1016/j.neuron.2016.10.018
– ident: e_1_3_7_95_2
  doi: 10.3389/fnagi.2016.00315
– volume: 318
  start-page: 85
  year: 1995
  ident: e_1_3_7_66_2
  article-title: Biochemical characterization of Tau proteins during cerebral aging of the lemurian primate Microcebus murinus
  publication-title: C. R. Acad. Sci. Ser. III Sci. Vie
– ident: e_1_3_7_94_2
  doi: 10.1002/dneu.22483
– ident: e_1_3_7_61_2
  doi: 10.1037/0735-7044.119.1.118
– volume: 32
  start-page: 615
  year: 1972
  ident: e_1_3_7_14_2
  article-title: Unity and diversity of frontal lobe functions
  publication-title: Acta Neurobiol. Exp.
– ident: e_1_3_7_54_2
  doi: 10.1002/cne.10099
– ident: e_1_3_7_59_2
  doi: 10.3389/fnagi.2012.00031
– ident: e_1_3_7_102_2
  doi: 10.1016/B978-1-4832-2821-1.50012-4
– ident: e_1_3_7_82_2
  doi: 10.1007/s004010100429
– ident: e_1_3_7_110_2
  doi: 10.1016/j.neuroimage.2014.06.053
– ident: e_1_3_7_22_2
  doi: 10.1016/j.neurobiolaging.2016.12.022
– ident: e_1_3_7_39_2
  doi: 10.1016/j.jalz.2018.06.3057
– ident: e_1_3_7_60_2
  doi: 10.1016/j.bbr.2004.12.003
– ident: e_1_3_7_55_2
  doi: 10.1016/j.neurobiolaging.2007.03.022
– ident: e_1_3_7_44_2
  doi: 10.1016/B978-012369391-4/50039-4
– ident: e_1_3_7_77_2
  doi: 10.1016/j.neurobiolaging.2009.05.018
– ident: e_1_3_7_111_2
  doi: 10.1016/j.neuroimage.2006.01.021
– ident: e_1_3_7_43_2
  doi: 10.1016/0197-4580(93)90055-G
– ident: e_1_3_7_41_2
  doi: 10.1016/0197-4580(93)90050-L
– ident: e_1_3_7_107_2
  doi: 10.1016/j.neurobiolaging.2018.08.018
– ident: e_1_3_7_86_2
  doi: 10.1016/B978-0-12-811829-0.00021-2
– ident: e_1_3_7_103_2
  doi: 10.1016/j.neurobiolaging.2013.08.036
– ident: e_1_3_7_101_2
  doi: 10.1093/geronj/16.4.381
– ident: e_1_3_7_64_2
  doi: 10.1098/rspb.2014.0830
– ident: e_1_3_7_88_2
  doi: 10.1016/j.neures.2017.06.002
– volume-title: Handbook of executive functioning
  year: 2013
  ident: e_1_3_7_6_2
– ident: e_1_3_7_70_2
– ident: e_1_3_7_48_2
  doi: 10.1016/S0197-4580(99)00097-4
– ident: e_1_3_7_99_2
  doi: 10.1016/j.tics.2013.09.013
– ident: e_1_3_7_75_2
  doi: 10.3389/fnbeh.2014.00446
– ident: e_1_3_7_24_2
  doi: 10.1001/archneur.56.3.338
– ident: e_1_3_7_85_2
  doi: 10.1093/ilar.52.1.54
– ident: e_1_3_7_18_2
  doi: 10.1016/j.neuroimage.2011.11.050
– ident: e_1_3_7_25_2
  doi: 10.1212/WNL.57.4.632
– ident: e_1_3_7_91_2
  doi: 10.1523/ENEURO.0154-19.2019
– ident: e_1_3_7_19_2
  doi: 10.1037/0882-7974.19.3.482
– ident: e_1_3_7_40_2
  doi: 10.1016/S0166-4328(96)02256-5
– ident: e_1_3_7_49_2
  doi: 10.1016/S0197-4580(02)00054-4
– ident: e_1_3_7_51_2
  doi: 10.1093/cercor/8.4.295
– ident: e_1_3_7_65_2
  doi: 10.1016/0197-4580(92)90016-Q
– ident: e_1_3_7_27_2
  doi: 10.1007/PL00005665
– ident: e_1_3_7_73_2
  doi: 10.1371/journal.pone.0109393
– volume-title: Primate cognition
  year: 1997
  ident: e_1_3_7_100_2
  doi: 10.1093/oso/9780195106237.001.0001
– ident: e_1_3_7_81_2
  doi: 10.1007/s10522-012-9388-1
– ident: e_1_3_7_5_2
  doi: 10.1037/h0054182
– ident: e_1_3_7_57_2
  doi: 10.1038/nature10243
– volume-title: Higher cortical functions in man
  year: 1966
  ident: e_1_3_7_13_2
– ident: e_1_3_7_17_2
  doi: 10.1002/hbm.20129
– ident: e_1_3_7_33_2
  doi: 10.1001/archneur.1963.00460070100010
– ident: e_1_3_7_10_2
  doi: 10.1006/cogp.1999.0734
– ident: e_1_3_7_26_2
  doi: 10.1016/j.neuropsychologia.2009.01.003
– volume: 7
  start-page: 17
  year: 1995
  ident: e_1_3_7_74_2
  article-title: Effects of aging upon recent memory in Microcebus murinus
  publication-title: Aging
– volume: 5
  start-page: 120
  year: 2006
  ident: e_1_3_7_68_2
  article-title: Microcebus murinus: a useful primate model for human cerebral aging and Alzheimer's disease? Genes
  publication-title: Brain Behav.
– ident: e_1_3_7_12_2
  doi: 10.1017/S1355617717000704
– ident: e_1_3_7_21_2
  doi: 10.1037/0882-7974.7.4.571
– ident: e_1_3_7_53_2
  doi: 10.1016/j.neuroscience.2012.09.077
– ident: e_1_3_7_80_2
  doi: 10.1016/j.neuroimage.2018.10.010
– ident: e_1_3_7_84_2
  doi: 10.1016/S0378-5955(98)00201-9
– ident: e_1_3_7_87_2
  doi: 10.1093/ilar.38.3.142
– ident: e_1_3_7_72_2
  doi: 10.1016/j.neurobiolaging.2010.09.009
– ident: e_1_3_7_3_2
  doi: 10.1098/rstb.2013.0483
– ident: e_1_3_7_63_2
  doi: 10.1037/0735-7044.116.3.387
– ident: e_1_3_7_11_2
  doi: 10.1016/j.cortex.2016.04.023
– ident: e_1_3_7_16_2
  doi: 10.1002/hbm.20128
– volume: 13
  start-page: 1
  year: 1936
  ident: e_1_3_7_34_2
  article-title: Studies of cerebral function in primates. I. The functions of the frontal association areas in monkeys
  publication-title: Comp. Psychol. Monogr.
– ident: e_1_3_7_52_2
  doi: 10.1523/JNEUROSCI.1852-07.2008
– ident: e_1_3_7_32_2
  doi: 10.1007/BF03393227
– ident: e_1_3_7_47_2
  doi: 10.1016/0197-4580(95)02014-4
– ident: e_1_3_7_89_2
  doi: 10.1016/j.neurobiolaging.2018.10.003
– ident: e_1_3_7_29_2
  doi: 10.1037/0033-2909.120.2.272
– ident: e_1_3_7_76_2
  doi: 10.1016/S0197-4580(00)00098-1
– ident: e_1_3_7_8_2
– ident: e_1_3_7_15_2
  doi: 10.1016/j.neubiorev.2014.02.005
– ident: e_1_3_7_38_2
  doi: 10.1016/B978-012351830-9/50028-7
– ident: e_1_3_7_90_2
  doi: 10.1002/ajp.22924
– ident: e_1_3_7_69_2
  doi: 10.1016/j.dib.2018.10.067
– ident: e_1_3_7_2_2
  doi: 10.1111/j.1365-3040.2009.01929.x
– ident: e_1_3_7_7_2
  doi: 10.1016/B978-0-12-564340-5.50019-6
– ident: e_1_3_7_30_2
  doi: 10.1002/ajp.22281
– ident: e_1_3_7_106_2
  doi: 10.1016/j.anbehav.2015.01.002
SSID ssj0009574
Score 2.5606754
SecondaryResourceType review_article
Snippet Executive function (EF) is a complex construct that reflects multiple higher-order cognitive processes such as planning, updating, inhibiting and set-shifting....
SourceID pubmedcentral
proquest
crossref
SourceType Open Access Repository
Aggregation Database
Enrichment Source
Index Database
StartPage 20190618
SubjectTerms Review
Title Age-related decline in executive function as a hallmark of cognitive ageing in primates: an overview of cognitive and neurobiological studies
URI https://www.proquest.com/docview/2444602539
https://pubmed.ncbi.nlm.nih.gov/PMC7540957
Volume 375
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1baxNBFB5iRfFFbFSMN0YQVMLG7O5kL75FaSkaq0ICeVtmZ2fagN2UZiPa_-B_9Kd4zlz2UitUX0LYTIbA-XIuM9_5DiHPk6KIg9wHCwjFPCYi6aWKBR7nPAhDCChKabXPw-hgwd4vJ8te71eLtbSt8pE4v7Sv5H-sCs_Artgl-w-WrTeFB_Ae7AuvYGF4vZKNp0fS080okDUWUuiMESVAvkuxNXreELXMKPDNkOu5KSf8zFLJHW0IHIrtazlF5YnKkORwYsU39COmr6W1vCyGWgTTyDeZrsoWGdEmup_diAS9oGqmkm8cK8EcXDjWKF5V6MkiI3RfsNnw7cgOymwaN0VDeJxxSHe3Zirk9KjU9_1Jw9vn5yZ0KBR4bC6bjk9WRWXoSKa3vka1IQtpxqE5gbJUaHsgAtUvHvKmLR8O8dYLUjOPZCQveWYdf2hmtjiEJ9brW0-OTfaRiQ1_hJlxiq0TkJ7nSA5MR25hV8_78FO2v5jNsvnecn6NXA-gkMEZGx--JC1ZaK0TXv-8WlY0ed3dvZs2NbVQl8nbSo3md8htW9PQqQHoLunJsk9uGOP96JObHy1_o092bSjZ0JdW7_zVXfKzBWNqYUxXJa1hTB2MKd9QTh2M6VrRGpfUwBi_52D8hvKSOhBfWFwW9AKIqQXxPbLY35u_O_DslBBPMBZVHtTb2E-dSOVDwhfIVEVKQlHAJAobsUIFwTiJ_SDOVR75ihW-Spkax0IG4JSkH94nO-W6lA8IHcd5OAHvBHtBYSExU8snAoqEXEQxOLMB8ZwRMmEl9HGSy9fMUDmSDI2WodEyNNqAvKjXnxrxmL-ufOZsmoF_x0s7Xsr1dpNB-s0iKEzCdEDijrHrLVEhvvtJuTrWSvEx1GMAsYdX2P0RudX8mR6TnepsK59Avl3lTzVkfwNGNOBm
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Age-related+decline+in+executive+function+as+a+hallmark+of+cognitive+ageing+in+primates%3A+an+overview+of+cognitive+and+neurobiological+studies&rft.jtitle=Philosophical+transactions+of+the+Royal+Society+of+London.+Series+B.+Biological+sciences&rft.au=Lacreuse%2C+Agn%C3%A8s&rft.au=Raz%2C+Naftali&rft.au=Schmidtke%2C+Daniel&rft.au=Hopkins%2C+William+D&rft.date=2020-11-09&rft.issn=1471-2970&rft.eissn=1471-2970&rft.volume=375&rft.issue=1811&rft.spage=20190618&rft_id=info:doi/10.1098%2Frstb.2019.0618&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0962-8436&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0962-8436&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0962-8436&client=summon