Continuous flow process for preparing budesonide

• Published in: Journal of flow chemistry Vol. 12; no. 2; pp. 237 - 246
• Main Authors: Phull, Manjinder Singh, Jadav, Surender Singh, Bohara, Chander Singh, Gundla, Rambabu, Mainkar, Prathama S
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 2022
• Subjects: Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Green Chemistry; Industrial Chemistry/Chemical Engineering; Inorganic Chemistry; Nanochemistry; Organic Chemistry; Epimers; Budesonide; Flow reactor; Glucocorticosteroid; Isomeric ratio

Budesonide, a glucocorticosteroid, is used as anti-asthmatic drug that became generic in 2019. Existing preparation methods of budesonide require utilization of corrosive acids and involve expensive purification process. Thus, a new cost-effective continuous flow process for the synthesis of budeson...