Innovative nanotechnologies for enhancing nucleic acids/gene therapy: Controlling intracellular trafficking to targeted biodistribution

• Published in: Biomaterials Vol. 218; p. 119329
• Main Authors: Nakamura, Takashi, Yamada, Yuma, Sato, Yusuke, Khalil, Ikramy A., Harashima, Hideyoshi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.10.2019
• Subjects: adjuvant; cancer immunotherapy; MEND; MITO-Porter; pH-sensitive cationic lipid; YSK; YSK; MEND; adjuvant; pH-sensitive cationic lipid; MITO-Porter; cancer immunotherapy

Nanomedicine promises to play an important role in next generation therapy, including Nucleic acid/Gene therapy. To accomplish this, innovative nanotechnologies will be needed to support nanomedicine by controlling not only the biodistribution but also the intracellular trafficking of macromolecules...