Advances in immunotyping of colorectal cancer

Immunotherapy has transformed treatment for various types of malignancy. However, the benefit of immunotherapy is limited to a minority of patients with mismatch-repair-deficient (dMMR) and microsatellite instability-high (MSI-H) (dMMR-MSI-H) colorectal cancer (CRC). Understanding the complexity and...

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Published inFrontiers in immunology Vol. 14; p. 1259461
Main Authors Wu, Yinhang, Zhuang, Jing, Qu, Zhanbo, Yang, Xi, Han, Shuwen
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 09.10.2023
Subjects
colorectal cancer
colorectal cancer subtypes
immune subtype
Immunology
immunotherapy
tumor immune microenvironment
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Summary:Immunotherapy has transformed treatment for various types of malignancy. However, the benefit of immunotherapy is limited to a minority of patients with mismatch-repair-deficient (dMMR) and microsatellite instability-high (MSI-H) (dMMR-MSI-H) colorectal cancer (CRC). Understanding the complexity and heterogeneity of the tumor immune microenvironment (TIME) and identifying immune-related CRC subtypes will improve antitumor immunotherapy. Here, we review the current status of immunotherapy and typing schemes for CRC. Immune subtypes have been identified based on TIME and prognostic gene signatures that can both partially explain clinical responses to immune checkpoint inhibitors and the prognosis of patients with CRC. Identifying immune subtypes will improve understanding of complex CRC tumor heterogeneity and refine current immunotherapeutic strategies.
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Reviewed by: Christian Augsberger, AstraZeneca, Germany; Jaya Lakshmi Thangaraj, University of California, San Diego, United States
These authors have contributed equally to this work and share first authorship
Edited by: Youssef Errami, Tulane University, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1259461