In situ gas foaming based on magnesium particle degradation: A novel approach to fabricate injectable macroporous hydrogels
Injectable hydrogels are attractive biomaterials for cell delivery in tissue engineering. However, the in vivo viability of transplanted cells remains limited. Typically, macroporous structures constructed in hydrogels are utilized to enhance oxygen and nutrients diffusion for cell survival and to p...
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Published in | Biomaterials Vol. 232; p. 119727 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
01.02.2020
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Abstract | Injectable hydrogels are attractive biomaterials for cell delivery in tissue engineering. However, the in vivo viability of transplanted cells remains limited. Typically, macroporous structures constructed in hydrogels are utilized to enhance oxygen and nutrients diffusion for cell survival and to promote integration between the material and host tissue. A new gas-foaming method to generate pores was proposed by directly adding Mg particles into cell-laden hydrogel solutions, taking advantage of the H2 gas formed during the degradation of Mg. The optimization design of the size and amount of Mg particles added into the hydrogels was investigated. Improved cell viability and proliferation were demonstrated in the group with Mg particles. Additionally, Mg2+ ions generated during Mg degradation facilitated the osteogenic differentiation of stem cells encapsulated in hydrogels. Extensive vascularized bone regeneration in the femoral defects of rats revealed that the use of Mg particles as the foaming agent is feasible, endowing injectable hydrogels with optimized porosity and enhanced bioactivity, and providing a new strategy for future designs of porous hydrogels in tissue engineering. |
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AbstractList | Injectable hydrogels are attractive biomaterials for cell delivery in tissue engineering. However, the in vivo viability of transplanted cells remains limited. Typically, macroporous structures constructed in hydrogels are utilized to enhance oxygen and nutrients diffusion for cell survival and to promote integration between the material and host tissue. A new gas-foaming method to generate pores was proposed by directly adding Mg particles into cell-laden hydrogel solutions, taking advantage of the H
gas formed during the degradation of Mg. The optimization design of the size and amount of Mg particles added into the hydrogels was investigated. Improved cell viability and proliferation were demonstrated in the group with Mg particles. Additionally, Mg
ions generated during Mg degradation facilitated the osteogenic differentiation of stem cells encapsulated in hydrogels. Extensive vascularized bone regeneration in the femoral defects of rats revealed that the use of Mg particles as the foaming agent is feasible, endowing injectable hydrogels with optimized porosity and enhanced bioactivity, and providing a new strategy for future designs of porous hydrogels in tissue engineering. Injectable hydrogels are attractive biomaterials for cell delivery in tissue engineering. However, the in vivo viability of transplanted cells remains limited. Typically, macroporous structures constructed in hydrogels are utilized to enhance oxygen and nutrients diffusion for cell survival and to promote integration between the material and host tissue. A new gas-foaming method to generate pores was proposed by directly adding Mg particles into cell-laden hydrogel solutions, taking advantage of the H2 gas formed during the degradation of Mg. The optimization design of the size and amount of Mg particles added into the hydrogels was investigated. Improved cell viability and proliferation were demonstrated in the group with Mg particles. Additionally, Mg2+ ions generated during Mg degradation facilitated the osteogenic differentiation of stem cells encapsulated in hydrogels. Extensive vascularized bone regeneration in the femoral defects of rats revealed that the use of Mg particles as the foaming agent is feasible, endowing injectable hydrogels with optimized porosity and enhanced bioactivity, and providing a new strategy for future designs of porous hydrogels in tissue engineering. |
ArticleNumber | 119727 |
Author | Jiang, Fei Yin, Shi Yang, Guangzheng Jiang, Xinquan Zhang, Wenjie Sun, Ningjia Lin, Sihan Tang, Yanmei Zhou, Mingliang |
Author_xml | – sequence: 1 givenname: Yanmei surname: Tang fullname: Tang, Yanmei organization: Department of Prosthodontics, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China – sequence: 2 givenname: Sihan surname: Lin fullname: Lin, Sihan organization: Department of Prosthodontics, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China – sequence: 3 givenname: Shi surname: Yin fullname: Yin, Shi organization: Department of Prosthodontics, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China – sequence: 4 givenname: Fei surname: Jiang fullname: Jiang, Fei organization: Department of Prosthodontics, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China – sequence: 5 givenname: Mingliang surname: Zhou fullname: Zhou, Mingliang organization: Department of Prosthodontics, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China – sequence: 6 givenname: Guangzheng surname: Yang fullname: Yang, Guangzheng organization: Department of Prosthodontics, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China – sequence: 7 givenname: Ningjia surname: Sun fullname: Sun, Ningjia organization: Department of Prosthodontics, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China – sequence: 8 givenname: Wenjie surname: Zhang fullname: Zhang, Wenjie email: zhangwenjie586@126.com organization: Department of Prosthodontics, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China – sequence: 9 givenname: Xinquan surname: Jiang fullname: Jiang, Xinquan email: xinquanj@aliyun.com organization: Department of Prosthodontics, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China |
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Cites_doi | 10.1002/adfm.201804335 10.1038/srep46161 10.1002/jbm.a.35570 10.1016/j.biomaterials.2018.04.026 10.1038/nmat2732 10.1016/j.biomaterials.2017.11.032 10.1002/jbm.a.31293 10.1002/jbm.b.33336 10.1088/1758-5090/8/3/035020 10.1007/s40778-016-0058-0 10.1002/advs.201900209 10.1016/j.actbio.2018.11.040 10.1038/nmat4407 10.3390/nano8110960 10.1016/j.actbio.2009.10.012 10.1016/j.actbio.2015.08.042 10.1016/j.actbio.2015.11.055 10.1016/j.cis.2017.07.012 10.1002/jbm.b.33088 10.1073/pnas.1006442107 10.1007/s10006-014-0453-6 10.1016/j.biomaterials.2010.03.031 10.1016/S0142-9612(00)00033-8 10.1080/10601320500406008 10.1002/term.1861 10.1016/j.biomaterials.2007.04.014 10.1002/adhm.201500618 10.1016/j.actbio.2009.12.048 10.1016/j.biomaterials.2018.05.011 10.1016/j.actbio.2018.10.016 10.1016/j.biomaterials.2011.07.001 10.1016/j.cocis.2018.10.010 10.1016/j.actbio.2018.03.047 10.3109/07853890.2015.1034765 10.1002/jbm.b.31877 10.1016/j.actbio.2017.08.051 10.1016/j.actbio.2014.02.002 10.1089/ten.tea.2017.0496 |
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Keywords | Cell viability Vascularized bone regeneration Magnesium Injectable hydrogel |
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References | Hilborn (bib1) 2011; 3 Luo, Pan, Sun, Zhang, Yang, Liu, Li, Xu, Sui, Wei (bib9) 2018 Kim, Yun, Choi, Kim, Choi, Kwon, Kim, Kwon, Bae, Kim, Bae, Shin, Park (bib42) 2018; 157 Zhang, Liu, Gauthier, Sourice, Pilet, Rethore, Khairoun, Bouler, Tancret, Weiss (bib27) 2016; 31 Eiselt, Yeh, Latvala, Shea, Mooney (bib15) 2000; 21 Huebsch, Lippens, Lee, Mehta, Koshy, Darnell, Desai, Madl, Xu, Zhao, Chaudhuri, Verbeke, Kim, Alim, Mammoto, Ingber, Duda, Mooney (bib11) 2015; 14 Li, Zhao, Su, Cui, Luo, Ma (bib23) 2011; 15 Beck-Broichsitter, Daschner, Christofzik, Knochel, Wiltfang, Becker (bib36) 2015; 19 Ribeiro, da Silva Morais, Maia, Canadas, Costa, Oliveira, Oliveira, Reis (bib22) 2018; 72 Wang, Li, Zuo, Li, Ma, Cheng (bib10) 2007; 28 Ostojic (bib18) 2015; 47 Ma, Zhao, Zhu (bib20) 2016; 104 Gupte, Swanson, Hu, Jin, Ma, Zhang, Liu, Feng, Feng, Xiao, Hatch, Mishina, Ma (bib28) 2018; 82 Verbeke, Mooney (bib4) 2015; 4 Marquardt, Heilshorn (bib5) 2016; 2 Zhang, Zu, Zhao, Yang, Tian, Yu, Lu, Liu, Yu, Wang, Wang, Huang, Wang, Wang, Zhang (bib41) 2017; 63 Mueller, Lucia Nascimento, Lorenzo de Mele (bib33) 2010; 6 Annabi, Nichol, Zhong, Ji, Koshy, Khademhosseini, Dehghani (bib16) 2010; 16 Flegeau, Pace, Gautier, Rethore, Guicheux, Le Visage, Weiss (bib14) 2017; 247 Witte, Ulrich, Palm, Willbold (bib12) 2007; 81 Wu, Feyerabend, Schilling, Willumeit-Romer, Luthringer (bib40) 2015; 27 Yoshizawa, Brown, Barchowsky, Sfeir (bib21) 2014; 10 Ouyang, Yao, Zhao, Sun (bib26) 2016; 8 Di Virgilio, Reigosa, de Mele (bib34) 2011; 99 Witte, Fischer, Nellesen, Vogt, Vogt, Donath, Beckmann (bib38) 2010; 6 Wang, Neumann, Fu, Li, Cheng, Su (bib6) 2018; 38 Leem, Lee, Kim, Seok, Chang, Lee (bib19) 2016; 10 Haugh, Vaughan, Madl, Raftery, McNamara, O'Brien, Heilshorn (bib7) 2018; 171 Steiner, Lingens, Fischer, Köhn, Detsch, Boccaccini, Fey, Greil, Weis, Beier (bib24) 2018; 24 Zhang, Lai, Li, Xu, Tang, Ci, Sun, Xu, Li (bib37) 2017; 7 Lin, Wu, Qiao, Zhao, Wong, Chu, Bian, Wu, Zheng, Cheung, Leung, Yeung (bib25) 2018; 174 Lin, Yang, Jiang, Zhou, Yin, Tang, Tang, Zhang, Zhang, Jiang (bib35) 2019 Huebsch, Arany, Mao, Shvartsman, Ali, Bencherif, Rivera-Feliciano, Mooney (bib30) 2010; 9 Cuchiara, Allen, Chen, Miller, West (bib3) 2010; 31 Zuidema, Rivet, Gilbert, Morrison (bib31) 2014; 102 Szot, Buchanan, Freeman, Rylander (bib2) 2011; 32 Noviana, Paramitha, Ulum, Hermawan (bib13) 2016; 5 Hasturk, Kaplan (bib39) 2019; 95 El‐Rehim, Hegazy, Diaa (bib17) 2007; 43 Madden, Mortisen, Sussman, Dupras, Fugate, Cuy, Hauch, Laflamme, Murry, Ratner (bib8) 2010; 107 Chen, Fan, Deng, Wu, Yi, Gu, Zhou, Fan, Zhang (bib29) 2018; 8 No, Roohani-Esfahani, Lu, Schaer, Zreiqat (bib32) 2015; 103 Cuchiara (10.1016/j.biomaterials.2019.119727_bib3) 2010; 31 Annabi (10.1016/j.biomaterials.2019.119727_bib16) 2010; 16 Zuidema (10.1016/j.biomaterials.2019.119727_bib31) 2014; 102 Verbeke (10.1016/j.biomaterials.2019.119727_bib4) 2015; 4 Haugh (10.1016/j.biomaterials.2019.119727_bib7) 2018; 171 Wu (10.1016/j.biomaterials.2019.119727_bib40) 2015; 27 Hilborn (10.1016/j.biomaterials.2019.119727_bib1) 2011; 3 Wang (10.1016/j.biomaterials.2019.119727_bib6) 2018; 38 Chen (10.1016/j.biomaterials.2019.119727_bib29) 2018; 8 Huebsch (10.1016/j.biomaterials.2019.119727_bib30) 2010; 9 Zhang (10.1016/j.biomaterials.2019.119727_bib41) 2017; 63 Witte (10.1016/j.biomaterials.2019.119727_bib12) 2007; 81 Ma (10.1016/j.biomaterials.2019.119727_bib20) 2016; 104 Leem (10.1016/j.biomaterials.2019.119727_bib19) 2016; 10 Szot (10.1016/j.biomaterials.2019.119727_bib2) 2011; 32 Lin (10.1016/j.biomaterials.2019.119727_bib25) 2018; 174 Steiner (10.1016/j.biomaterials.2019.119727_bib24) 2018; 24 Eiselt (10.1016/j.biomaterials.2019.119727_bib15) 2000; 21 Ostojic (10.1016/j.biomaterials.2019.119727_bib18) 2015; 47 Witte (10.1016/j.biomaterials.2019.119727_bib38) 2010; 6 Beck-Broichsitter (10.1016/j.biomaterials.2019.119727_bib36) 2015; 19 Lin (10.1016/j.biomaterials.2019.119727_bib35) 2019 Huebsch (10.1016/j.biomaterials.2019.119727_bib11) 2015; 14 No (10.1016/j.biomaterials.2019.119727_bib32) 2015; 103 El‐Rehim (10.1016/j.biomaterials.2019.119727_bib17) 2007; 43 Yoshizawa (10.1016/j.biomaterials.2019.119727_bib21) 2014; 10 Li (10.1016/j.biomaterials.2019.119727_bib23) 2011; 15 Ribeiro (10.1016/j.biomaterials.2019.119727_bib22) 2018; 72 Ouyang (10.1016/j.biomaterials.2019.119727_bib26) 2016; 8 Wang (10.1016/j.biomaterials.2019.119727_bib10) 2007; 28 Zhang (10.1016/j.biomaterials.2019.119727_bib37) 2017; 7 Kim (10.1016/j.biomaterials.2019.119727_bib42) 2018; 157 Marquardt (10.1016/j.biomaterials.2019.119727_bib5) 2016; 2 Di Virgilio (10.1016/j.biomaterials.2019.119727_bib34) 2011; 99 Hasturk (10.1016/j.biomaterials.2019.119727_bib39) 2019; 95 Noviana (10.1016/j.biomaterials.2019.119727_bib13) 2016; 5 Gupte (10.1016/j.biomaterials.2019.119727_bib28) 2018; 82 Zhang (10.1016/j.biomaterials.2019.119727_bib27) 2016; 31 Luo (10.1016/j.biomaterials.2019.119727_bib9) 2018 Flegeau (10.1016/j.biomaterials.2019.119727_bib14) 2017; 247 Madden (10.1016/j.biomaterials.2019.119727_bib8) 2010; 107 Mueller (10.1016/j.biomaterials.2019.119727_bib33) 2010; 6 |
References_xml | – start-page: 1900209 year: 2019 ident: bib35 article-title: A magnesium‐enriched 3D culture system that mimics the bone development microenvironment for vascularized bone regeneration publication-title: Adv. sci. contributor: fullname: Jiang – volume: 174 start-page: 1 year: 2018 end-page: 16 ident: bib25 article-title: Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration publication-title: Biomaterials contributor: fullname: Yeung – volume: 47 start-page: 301 year: 2015 end-page: 304 ident: bib18 article-title: Molecular hydrogen: an inert gas turns clinically effective publication-title: Ann. Med. contributor: fullname: Ostojic – volume: 247 start-page: 589 year: 2017 end-page: 609 ident: bib14 article-title: Toward the development of biomimetic injectable and macroporous biohydrogels for regenerative medicine publication-title: Adv. Colloid Interface Sci. contributor: fullname: Weiss – volume: 19 start-page: 55 year: 2015 end-page: 60 ident: bib36 article-title: Using eddy currents for noninvasive in vivo pH monitoring for bone tissue engineering publication-title: Oral Maxillofac. Surg. contributor: fullname: Becker – volume: 104 start-page: 347 year: 2016 end-page: 356 ident: bib20 article-title: Biphasic responses of human vascular smooth muscle cells to magnesium ion publication-title: J. Biomed. Mater. Res. A contributor: fullname: Zhu – volume: 6 start-page: 1749 year: 2010 end-page: 1755 ident: bib33 article-title: Critical discussion of the results from different corrosion studies of Mg and Mg alloys for biomaterial applications publication-title: Acta Biomater. contributor: fullname: Lorenzo de Mele – volume: 2 start-page: 207 year: 2016 end-page: 220 ident: bib5 article-title: Design of injectable materials to improve stem cell transplantation publication-title: Curr. Stem Cell Rep. contributor: fullname: Heilshorn – volume: 8 year: 2016 ident: bib26 article-title: Effect of bioink properties on printability and cell viability for 3D bioplotting of embryonic stem cells publication-title: Biofabrication contributor: fullname: Sun – volume: 95 start-page: 3 year: 2019 end-page: 31 ident: bib39 article-title: Cell armor for protection against environmental stress: advances, challenges and applications in micro- and nanoencapsulation of mammalian cells publication-title: Acta Biomater. contributor: fullname: Kaplan – volume: 99 start-page: 111 year: 2011 end-page: 119 ident: bib34 article-title: Biocompatibility of magnesium particles evaluated by in vitro cytotoxicity and genotoxicity assays publication-title: J. Biomed. Mater. Res. B Appl. Biomater. contributor: fullname: de Mele – volume: 28 start-page: 3338 year: 2007 end-page: 3348 ident: bib10 article-title: Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering publication-title: Biomaterials contributor: fullname: Cheng – volume: 81 start-page: 757 year: 2007 end-page: 765 ident: bib12 article-title: Biodegradable magnesium scaffolds: Part II: peri-implant bone remodeling publication-title: J. Biomed. Mater. Res. A contributor: fullname: Willbold – volume: 4 start-page: 2677 year: 2015 end-page: 2687 ident: bib4 article-title: Injectable, pore-forming hydrogels for in vivo enrichment of immature dendritic cells publication-title: Adv. Healthc. Mater. contributor: fullname: Mooney – volume: 14 start-page: 1269 year: 2015 end-page: 1277 ident: bib11 article-title: Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation publication-title: Nat. Mater. contributor: fullname: Mooney – volume: 6 start-page: 1792 year: 2010 end-page: 1799 ident: bib38 article-title: In vivo corrosion and corrosion protection of magnesium alloy LAE442 publication-title: Acta Biomater. contributor: fullname: Beckmann – volume: 82 start-page: 1 year: 2018 end-page: 11 ident: bib28 article-title: Pore size directs bone marrow stromal cell fate and tissue regeneration in nanofibrous macroporous scaffolds by mediating vascularization publication-title: Acta Biomater. contributor: fullname: Ma – volume: 43 start-page: 101 year: 2007 end-page: 113 ident: bib17 article-title: Characterization of super‐absorbent material based on carboxymethylcellulose sodium salt prepared by electron beam irradiation publication-title: J. Macromol. Sci., Part A contributor: fullname: Diaa – volume: 3 start-page: 589 year: 2011 end-page: 606 ident: bib1 article-title: In vivo injectable gels for tissue repair publication-title: Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol. contributor: fullname: Hilborn – volume: 7 start-page: 46161 year: 2017 ident: bib37 article-title: Acidic pH environment induces autophagy in osteoblasts publication-title: Sci. Rep. contributor: fullname: Li – volume: 5 start-page: 9 year: 2016 end-page: 15 ident: bib13 article-title: The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats publication-title: J. Orthop. Transl. contributor: fullname: Hermawan – volume: 171 start-page: 23 year: 2018 end-page: 33 ident: bib7 article-title: Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates publication-title: Biomaterials contributor: fullname: Heilshorn – volume: 21 start-page: 1921 year: 2000 end-page: 1927 ident: bib15 article-title: Porous carriers for biomedical applications based on alginate hydrogels publication-title: Biomaterials contributor: fullname: Mooney – volume: 9 start-page: 518 year: 2010 end-page: 526 ident: bib30 article-title: Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate publication-title: Nat. Mater. contributor: fullname: Mooney – volume: 72 start-page: 167 year: 2018 end-page: 181 ident: bib22 article-title: Combinatory approach for developing silk fibroin scaffolds for cartilage regeneration publication-title: Acta Biomater. contributor: fullname: Reis – volume: 10 start-page: 2834 year: 2014 end-page: 2842 ident: bib21 article-title: Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation publication-title: Acta Biomater. contributor: fullname: Sfeir – volume: 8 year: 2018 ident: bib29 article-title: Scaffold structural microenvironmental cues to guide tissue regeneration in bone tissue applications publication-title: Nanomaterials contributor: fullname: Zhang – volume: 16 start-page: 371 year: 2010 end-page: 383 ident: bib16 article-title: Controlling the porosity and microarchitecture of hydrogels for tissue engineering, Tissue engineering publication-title: Part B, Rev. contributor: fullname: Dehghani – start-page: 1804335 year: 2018 ident: bib9 article-title: Injectable 3D porous micro-scaffolds with a bio-engine for cell transplantation and tissue regeneration publication-title: Adv. Funct. Mater. contributor: fullname: Wei – volume: 32 start-page: 7905 year: 2011 end-page: 7912 ident: bib2 article-title: 3D in vitro bioengineered tumors based on collagen I hydrogels publication-title: Biomaterials contributor: fullname: Rylander – volume: 38 start-page: 135 year: 2018 end-page: 157 ident: bib6 article-title: Porous and responsive hydrogels for cell therapy publication-title: Curr. Opin. Colloid Interface Sci. contributor: fullname: Su – volume: 103 start-page: 1465 year: 2015 end-page: 1477 ident: bib32 article-title: Injectable radiopaque and bioactive polycaprolactone-ceramic composites for orthopedic augmentation publication-title: J. Biomed. Mater. Res. B Appl. Biomater. contributor: fullname: Zreiqat – volume: 27 start-page: 294 year: 2015 end-page: 304 ident: bib40 article-title: Effects of extracellular magnesium extract on the proliferation and differentiation of human osteoblasts and osteoclasts in coculture publication-title: Acta Biomater. contributor: fullname: Luthringer – volume: 31 start-page: 326 year: 2016 end-page: 338 ident: bib27 article-title: A simple and effective approach to prepare injectable macroporous calcium phosphate cement for bone repair: syringe-foaming using a viscous hydrophilic polymeric solution publication-title: Acta Biomater. contributor: fullname: Weiss – volume: 157 start-page: 51 year: 2018 end-page: 61 ident: bib42 article-title: Magnesium phosphate ceramics incorporating a novel indene compound promote osteoblast differentiation in vitro and bone regeneration in vivo publication-title: Biomaterials contributor: fullname: Park – volume: 31 start-page: 5491 year: 2010 end-page: 5497 ident: bib3 article-title: Multilayer microfluidic PEGDA hydrogels publication-title: Biomaterials contributor: fullname: West – volume: 107 start-page: 15211 year: 2010 end-page: 15216 ident: bib8 article-title: Proangiogenic scaffolds as functional templates for cardiac tissue engineering publication-title: Proc. Natl. Acad. Sci. U. S. A contributor: fullname: Ratner – volume: 15 start-page: 1721 year: 2011 end-page: 1725 ident: bib23 article-title: Culture and identification of rat bone marrow mesenchymal stem cells publication-title: J. Clin. Rehabilitative Tissue Eng. Res. contributor: fullname: Ma – volume: 10 start-page: E527 year: 2016 end-page: E536 ident: bib19 article-title: Magnesium ions facilitate integrin alpha 2- and alpha 3-mediated proliferation and enhance alkaline phosphatase expression and activity in hBMSCs publication-title: J. Tissue Eng. Regenerat. Med. contributor: fullname: Lee – volume: 24 start-page: 1320 year: 2018 end-page: 1331 ident: bib24 article-title: Encapsulation of mesenchymal stem cells improves vascularization of alginate-based scaffolds publication-title: Tissue Eng. A contributor: fullname: Beier – volume: 102 start-page: 1063 year: 2014 end-page: 1073 ident: bib31 article-title: A protocol for rheological characterization of hydrogels for tissue engineering strategies publication-title: J. Biomed. Mater. Res. B Appl. Biomater. contributor: fullname: Morrison – volume: 63 start-page: 369 year: 2017 end-page: 382 ident: bib41 article-title: Ion channel functional protein kinase TRPM7 regulates Mg ions to promote the osteoinduction of human osteoblast via PI3K pathway: in vitro simulation of the bone-repairing effect of Mg-based alloy implant publication-title: Acta Biomater. contributor: fullname: Zhang – start-page: 1804335 year: 2018 ident: 10.1016/j.biomaterials.2019.119727_bib9 article-title: Injectable 3D porous micro-scaffolds with a bio-engine for cell transplantation and tissue regeneration publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201804335 contributor: fullname: Luo – volume: 3 start-page: 589 issue: 6 year: 2011 ident: 10.1016/j.biomaterials.2019.119727_bib1 article-title: In vivo injectable gels for tissue repair publication-title: Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol. contributor: fullname: Hilborn – volume: 7 start-page: 46161 year: 2017 ident: 10.1016/j.biomaterials.2019.119727_bib37 article-title: Acidic pH environment induces autophagy in osteoblasts publication-title: Sci. Rep. doi: 10.1038/srep46161 contributor: fullname: Zhang – volume: 104 start-page: 347 issue: 2 year: 2016 ident: 10.1016/j.biomaterials.2019.119727_bib20 article-title: Biphasic responses of human vascular smooth muscle cells to magnesium ion publication-title: J. Biomed. Mater. Res. A doi: 10.1002/jbm.a.35570 contributor: fullname: Ma – volume: 171 start-page: 23 year: 2018 ident: 10.1016/j.biomaterials.2019.119727_bib7 article-title: Investigating the interplay between substrate stiffness and ligand chemistry in directing mesenchymal stem cell differentiation within 3D macro-porous substrates publication-title: Biomaterials doi: 10.1016/j.biomaterials.2018.04.026 contributor: fullname: Haugh – volume: 9 start-page: 518 issue: 6 year: 2010 ident: 10.1016/j.biomaterials.2019.119727_bib30 article-title: Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate publication-title: Nat. Mater. doi: 10.1038/nmat2732 contributor: fullname: Huebsch – volume: 157 start-page: 51 year: 2018 ident: 10.1016/j.biomaterials.2019.119727_bib42 article-title: Magnesium phosphate ceramics incorporating a novel indene compound promote osteoblast differentiation in vitro and bone regeneration in vivo publication-title: Biomaterials doi: 10.1016/j.biomaterials.2017.11.032 contributor: fullname: Kim – volume: 81 start-page: 757 issue: 3 year: 2007 ident: 10.1016/j.biomaterials.2019.119727_bib12 article-title: Biodegradable magnesium scaffolds: Part II: peri-implant bone remodeling publication-title: J. Biomed. Mater. Res. A doi: 10.1002/jbm.a.31293 contributor: fullname: Witte – volume: 103 start-page: 1465 issue: 7 year: 2015 ident: 10.1016/j.biomaterials.2019.119727_bib32 article-title: Injectable radiopaque and bioactive polycaprolactone-ceramic composites for orthopedic augmentation publication-title: J. Biomed. Mater. Res. B Appl. Biomater. doi: 10.1002/jbm.b.33336 contributor: fullname: No – volume: 8 issue: 3 year: 2016 ident: 10.1016/j.biomaterials.2019.119727_bib26 article-title: Effect of bioink properties on printability and cell viability for 3D bioplotting of embryonic stem cells publication-title: Biofabrication doi: 10.1088/1758-5090/8/3/035020 contributor: fullname: Ouyang – volume: 2 start-page: 207 issue: 3 year: 2016 ident: 10.1016/j.biomaterials.2019.119727_bib5 article-title: Design of injectable materials to improve stem cell transplantation publication-title: Curr. Stem Cell Rep. doi: 10.1007/s40778-016-0058-0 contributor: fullname: Marquardt – start-page: 1900209 year: 2019 ident: 10.1016/j.biomaterials.2019.119727_bib35 article-title: A magnesium‐enriched 3D culture system that mimics the bone development microenvironment for vascularized bone regeneration publication-title: Adv. sci. doi: 10.1002/advs.201900209 contributor: fullname: Lin – volume: 95 start-page: 3 year: 2019 ident: 10.1016/j.biomaterials.2019.119727_bib39 article-title: Cell armor for protection against environmental stress: advances, challenges and applications in micro- and nanoencapsulation of mammalian cells publication-title: Acta Biomater. doi: 10.1016/j.actbio.2018.11.040 contributor: fullname: Hasturk – volume: 14 start-page: 1269 issue: 12 year: 2015 ident: 10.1016/j.biomaterials.2019.119727_bib11 article-title: Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation publication-title: Nat. Mater. doi: 10.1038/nmat4407 contributor: fullname: Huebsch – volume: 8 issue: 11 year: 2018 ident: 10.1016/j.biomaterials.2019.119727_bib29 article-title: Scaffold structural microenvironmental cues to guide tissue regeneration in bone tissue applications publication-title: Nanomaterials doi: 10.3390/nano8110960 contributor: fullname: Chen – volume: 6 start-page: 1792 issue: 5 year: 2010 ident: 10.1016/j.biomaterials.2019.119727_bib38 article-title: In vivo corrosion and corrosion protection of magnesium alloy LAE442 publication-title: Acta Biomater. doi: 10.1016/j.actbio.2009.10.012 contributor: fullname: Witte – volume: 27 start-page: 294 year: 2015 ident: 10.1016/j.biomaterials.2019.119727_bib40 article-title: Effects of extracellular magnesium extract on the proliferation and differentiation of human osteoblasts and osteoclasts in coculture publication-title: Acta Biomater. doi: 10.1016/j.actbio.2015.08.042 contributor: fullname: Wu – volume: 31 start-page: 326 year: 2016 ident: 10.1016/j.biomaterials.2019.119727_bib27 article-title: A simple and effective approach to prepare injectable macroporous calcium phosphate cement for bone repair: syringe-foaming using a viscous hydrophilic polymeric solution publication-title: Acta Biomater. doi: 10.1016/j.actbio.2015.11.055 contributor: fullname: Zhang – volume: 247 start-page: 589 year: 2017 ident: 10.1016/j.biomaterials.2019.119727_bib14 article-title: Toward the development of biomimetic injectable and macroporous biohydrogels for regenerative medicine publication-title: Adv. Colloid Interface Sci. doi: 10.1016/j.cis.2017.07.012 contributor: fullname: Flegeau – volume: 15 start-page: 1721 year: 2011 ident: 10.1016/j.biomaterials.2019.119727_bib23 article-title: Culture and identification of rat bone marrow mesenchymal stem cells publication-title: J. Clin. Rehabilitative Tissue Eng. Res. contributor: fullname: Li – volume: 102 start-page: 1063 issue: 5 year: 2014 ident: 10.1016/j.biomaterials.2019.119727_bib31 article-title: A protocol for rheological characterization of hydrogels for tissue engineering strategies publication-title: J. Biomed. Mater. Res. B Appl. Biomater. doi: 10.1002/jbm.b.33088 contributor: fullname: Zuidema – volume: 107 start-page: 15211 issue: 34 year: 2010 ident: 10.1016/j.biomaterials.2019.119727_bib8 article-title: Proangiogenic scaffolds as functional templates for cardiac tissue engineering publication-title: Proc. Natl. Acad. Sci. U. S. A doi: 10.1073/pnas.1006442107 contributor: fullname: Madden – volume: 19 start-page: 55 issue: 1 year: 2015 ident: 10.1016/j.biomaterials.2019.119727_bib36 article-title: Using eddy currents for noninvasive in vivo pH monitoring for bone tissue engineering publication-title: Oral Maxillofac. Surg. doi: 10.1007/s10006-014-0453-6 contributor: fullname: Beck-Broichsitter – volume: 31 start-page: 5491 issue: 21 year: 2010 ident: 10.1016/j.biomaterials.2019.119727_bib3 article-title: Multilayer microfluidic PEGDA hydrogels publication-title: Biomaterials doi: 10.1016/j.biomaterials.2010.03.031 contributor: fullname: Cuchiara – volume: 21 start-page: 1921 issue: 19 year: 2000 ident: 10.1016/j.biomaterials.2019.119727_bib15 article-title: Porous carriers for biomedical applications based on alginate hydrogels publication-title: Biomaterials doi: 10.1016/S0142-9612(00)00033-8 contributor: fullname: Eiselt – volume: 43 start-page: 101 issue: 1 year: 2007 ident: 10.1016/j.biomaterials.2019.119727_bib17 article-title: Characterization of super‐absorbent material based on carboxymethylcellulose sodium salt prepared by electron beam irradiation publication-title: J. Macromol. Sci., Part A doi: 10.1080/10601320500406008 contributor: fullname: El‐Rehim – volume: 10 start-page: E527 issue: 10 year: 2016 ident: 10.1016/j.biomaterials.2019.119727_bib19 article-title: Magnesium ions facilitate integrin alpha 2- and alpha 3-mediated proliferation and enhance alkaline phosphatase expression and activity in hBMSCs publication-title: J. Tissue Eng. Regenerat. Med. doi: 10.1002/term.1861 contributor: fullname: Leem – volume: 28 start-page: 3338 issue: 22 year: 2007 ident: 10.1016/j.biomaterials.2019.119727_bib10 article-title: Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering publication-title: Biomaterials doi: 10.1016/j.biomaterials.2007.04.014 contributor: fullname: Wang – volume: 4 start-page: 2677 issue: 17 year: 2015 ident: 10.1016/j.biomaterials.2019.119727_bib4 article-title: Injectable, pore-forming hydrogels for in vivo enrichment of immature dendritic cells publication-title: Adv. Healthc. Mater. doi: 10.1002/adhm.201500618 contributor: fullname: Verbeke – volume: 6 start-page: 1749 issue: 5 year: 2010 ident: 10.1016/j.biomaterials.2019.119727_bib33 article-title: Critical discussion of the results from different corrosion studies of Mg and Mg alloys for biomaterial applications publication-title: Acta Biomater. doi: 10.1016/j.actbio.2009.12.048 contributor: fullname: Mueller – volume: 174 start-page: 1 year: 2018 ident: 10.1016/j.biomaterials.2019.119727_bib25 article-title: Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration publication-title: Biomaterials doi: 10.1016/j.biomaterials.2018.05.011 contributor: fullname: Lin – volume: 82 start-page: 1 year: 2018 ident: 10.1016/j.biomaterials.2019.119727_bib28 article-title: Pore size directs bone marrow stromal cell fate and tissue regeneration in nanofibrous macroporous scaffolds by mediating vascularization publication-title: Acta Biomater. doi: 10.1016/j.actbio.2018.10.016 contributor: fullname: Gupte – volume: 32 start-page: 7905 issue: 31 year: 2011 ident: 10.1016/j.biomaterials.2019.119727_bib2 article-title: 3D in vitro bioengineered tumors based on collagen I hydrogels publication-title: Biomaterials doi: 10.1016/j.biomaterials.2011.07.001 contributor: fullname: Szot – volume: 38 start-page: 135 year: 2018 ident: 10.1016/j.biomaterials.2019.119727_bib6 article-title: Porous and responsive hydrogels for cell therapy publication-title: Curr. Opin. Colloid Interface Sci. doi: 10.1016/j.cocis.2018.10.010 contributor: fullname: Wang – volume: 72 start-page: 167 year: 2018 ident: 10.1016/j.biomaterials.2019.119727_bib22 article-title: Combinatory approach for developing silk fibroin scaffolds for cartilage regeneration publication-title: Acta Biomater. doi: 10.1016/j.actbio.2018.03.047 contributor: fullname: Ribeiro – volume: 47 start-page: 301 issue: 4 year: 2015 ident: 10.1016/j.biomaterials.2019.119727_bib18 article-title: Molecular hydrogen: an inert gas turns clinically effective publication-title: Ann. Med. doi: 10.3109/07853890.2015.1034765 contributor: fullname: Ostojic – volume: 99 start-page: 111 issue: 1 year: 2011 ident: 10.1016/j.biomaterials.2019.119727_bib34 article-title: Biocompatibility of magnesium particles evaluated by in vitro cytotoxicity and genotoxicity assays publication-title: J. Biomed. Mater. Res. B Appl. Biomater. doi: 10.1002/jbm.b.31877 contributor: fullname: Di Virgilio – volume: 16 start-page: 371 issue: 4 year: 2010 ident: 10.1016/j.biomaterials.2019.119727_bib16 article-title: Controlling the porosity and microarchitecture of hydrogels for tissue engineering, Tissue engineering publication-title: Part B, Rev. contributor: fullname: Annabi – volume: 5 start-page: 9 year: 2016 ident: 10.1016/j.biomaterials.2019.119727_bib13 article-title: The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats publication-title: J. Orthop. Transl. contributor: fullname: Noviana – volume: 63 start-page: 369 year: 2017 ident: 10.1016/j.biomaterials.2019.119727_bib41 article-title: Ion channel functional protein kinase TRPM7 regulates Mg ions to promote the osteoinduction of human osteoblast via PI3K pathway: in vitro simulation of the bone-repairing effect of Mg-based alloy implant publication-title: Acta Biomater. doi: 10.1016/j.actbio.2017.08.051 contributor: fullname: Zhang – volume: 10 start-page: 2834 issue: 6 year: 2014 ident: 10.1016/j.biomaterials.2019.119727_bib21 article-title: Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation publication-title: Acta Biomater. doi: 10.1016/j.actbio.2014.02.002 contributor: fullname: Yoshizawa – volume: 24 start-page: 1320 issue: 17–18 year: 2018 ident: 10.1016/j.biomaterials.2019.119727_bib24 article-title: Encapsulation of mesenchymal stem cells improves vascularization of alginate-based scaffolds publication-title: Tissue Eng. 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Snippet | Injectable hydrogels are attractive biomaterials for cell delivery in tissue engineering. However, the in vivo viability of transplanted cells remains limited.... |
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SubjectTerms | Animals Bone Regeneration Cell viability Hydrogels Injectable hydrogel Magnesium Osteogenesis Rats Tissue Engineering Vascularized bone regeneration |
Title | In situ gas foaming based on magnesium particle degradation: A novel approach to fabricate injectable macroporous hydrogels |
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