Status epilepticus-induced changes in the subcellular distribution and activity of calcineurin in rat forebrain

This study was performed to determine the effect of prolonged status epilepticus on the activity and subcellular location of a neuronally enriched, calcium-regulated enzyme, calcineurin. Brain fractions isolated from control animals and rats subjected to pilocarpine-induced status epilepticus were s...

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Published inNeurobiology of disease Vol. 14; no. 3; pp. 483 - 493
Main Authors Kurz, Jonathan E, Rana, Annu, Parsons, J.Travis, Churn, Severn B
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.2003
Elsevier
Subjects
Animals
Calcineurin - metabolism
Calcium - metabolism
Calcium Signaling - physiology
Cell Compartmentation - physiology
Cell Nucleus - enzymology
Cerebral Cortex - enzymology
Cerebral Cortex - physiopathology
Dendrites - enzymology
Dendrites - ultrastructure
Disease Models, Animal
Hippocampus - enzymology
Hippocampus - physiopathology
Male
Nitrophenols - metabolism
Organophosphorus Compounds - metabolism
Phosphorylation
Pilocarpine - pharmacology
Prosencephalon - enzymology
Prosencephalon - physiopathology
Pyramidal Cells - cytology
Pyramidal Cells - enzymology
Rats
Rats, Sprague-Dawley
Status Epilepticus - chemically induced
Status Epilepticus - enzymology
Status Epilepticus - physiopathology
Synaptic Membranes - enzymology
Synaptosomes - enzymology
Up-Regulation - physiology
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Abstract This study was performed to determine the effect of prolonged status epilepticus on the activity and subcellular location of a neuronally enriched, calcium-regulated enzyme, calcineurin. Brain fractions isolated from control animals and rats subjected to pilocarpine-induced status epilepticus were subjected to differential centrifugation. Specific subcellular fractions were tested for both calcineurin activity and enzyme content. Significant, status epilepticus-induced increases in calcineurin activity were found in homogenates, nuclear fractions, and crude synaptic membrane-enriched fractions isolated from both cortex and hippocampus. Additionally, significant increases in enzyme levels were observed in crude synaptic fractions as measured by Western analysis. Immunohistochemical studies revealed a status epilepticus-induced increase in calcineurin immunoreactivity in dendritic structures of pyramidal neurons of the hippocampus. The data demonstrate a status epilepticus-induced increase in calcineurin activity and concentration in the postsynaptic region of forebrain pyramidal neurons.
AbstractList This study was performed to determine the effect of prolonged status epilepticus on the activity and subcellular location of a neuronally enriched, calcium-regulated enzyme, calcineurin. Brain fractions isolated from control animals and rats subjected to pilocarpine-induced status epilepticus were subjected to differential centrifugation. Specific subcellular fractions were tested for both calcineurin activity and enzyme content. Significant, status epilepticus-induced increases in calcineurin activity were found in homogenates, nuclear fractions, and crude synaptic membrane-enriched fractions isolated from both cortex and hippocampus. Additionally, significant increases in enzyme levels were observed in crude synaptic fractions as measured by Western analysis. Immunohistochemical studies revealed a status epilepticus-induced increase in calcineurin immunoreactivity in dendritic structures of pyramidal neurons of the hippocampus. The data demonstrate a status epilepticus-induced increase in calcineurin activity and concentration in the postsynaptic region of forebrain pyramidal neurons.
Author Kurz, Jonathan E
Churn, Severn B
Rana, Annu
Parsons, J.Travis
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Snippet This study was performed to determine the effect of prolonged status epilepticus on the activity and subcellular location of a neuronally enriched,...
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SubjectTerms Animals
Calcineurin - metabolism
Calcium - metabolism
Calcium Signaling - physiology
Cell Compartmentation - physiology
Cell Nucleus - enzymology
Cerebral Cortex - enzymology
Cerebral Cortex - physiopathology
Dendrites - enzymology
Dendrites - ultrastructure
Disease Models, Animal
Hippocampus - enzymology
Hippocampus - physiopathology
Male
Nitrophenols - metabolism
Organophosphorus Compounds - metabolism
Phosphorylation
Pilocarpine - pharmacology
Prosencephalon - enzymology
Prosencephalon - physiopathology
Pyramidal Cells - cytology
Pyramidal Cells - enzymology
Rats
Rats, Sprague-Dawley
Status Epilepticus - chemically induced
Status Epilepticus - enzymology
Status Epilepticus - physiopathology
Synaptic Membranes - enzymology
Synaptosomes - enzymology
Up-Regulation - physiology
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Title Status epilepticus-induced changes in the subcellular distribution and activity of calcineurin in rat forebrain
URI https://dx.doi.org/10.1016/j.nbd.2003.08.018
https://www.ncbi.nlm.nih.gov/pubmed/14678764
https://search.proquest.com/docview/20533629
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