Efficient selenium transfer from mother to offspring in selenoprotein-P-deficient mice enables dose-dependent rescue of phenotypes associated with selenium deficiency

Mice deficient in selenoprotein P exhibit a disturbed selenium distribution and reduced activities of other selenoenzymes and display defects in growth and motor co-ordination. We have normalized selenoenzyme activities and rescued the phenotype of mutant mice by supplementing their nursing mothers...

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Bibliographic Details
Published inBiochemical journal Vol. 378; no. Pt 1; pp. 21 - 26
Main Authors Schweizer, Ulrich, Michaelis, Marten, Köhrle, Josef, Schomburg, Lutz
Format Journal Article
LanguageEnglish
Published England 15.02.2004
Subjects
Administration, Oral
Animals
Behavior, Animal
Deficiency Diseases - metabolism
Deficiency Diseases - therapy
Dose-Response Relationship, Drug
Drinking
Female
Glutathione Peroxidase - blood
Mice
Mice, Knockout
Milk - chemistry
Movement Disorders - therapy
Phenotype
Pregnancy
Proteins - genetics
Selenium - analysis
Selenium - blood
Selenium - deficiency
Selenoprotein P
Selenoproteins
Sodium Selenite - administration & dosage
Sodium Selenite - therapeutic use
Weight Gain
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Summary:Mice deficient in selenoprotein P exhibit a disturbed selenium distribution and reduced activities of other selenoenzymes and display defects in growth and motor co-ordination. We have normalized selenoenzyme activities and rescued the phenotype of mutant mice by supplementing their nursing mothers with sodium selenite. Our results indicate that selenium from inorganic sources can be transferred efficiently via mother's milk to the developing offspring in a form that is both highly bioavailable by target tissues and yet sufficiently safe to prevent overdosages.
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ISSN:0264-6021
1470-8728
DOI:10.1042/BJ20031795