Interethnic differences of cytochrome P450 gene polymorphisms may influence outcome of taxane therapy in Roma and Hungarian populations

• Published in: Drug metabolism and pharmacokinetics Vol. 30; no. 6; pp. 453 - 456
• Main Authors: Szalai, Renata, Ganczer, Alma, Magyari, Lili, Matyas, Petra, Bene, Judit, Melegh, Bela
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2015
• Subjects: Adult; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; CYP1B1; CYP2C8; CYP3A5; Cytochrome P-450 CYP1B1 - genetics; Cytochrome P-450 CYP1B1 - metabolism; Cytochrome P-450 CYP2C8 - genetics; Cytochrome P-450 CYP2C8 - metabolism; Cytochrome P-450 CYP3A - genetics; Cytochrome P-450 CYP3A - metabolism; European Continental Ancestry Group - genetics; Female; Gene Frequency; Homozygote; Humans; Hungarian; Hungary; Male; Metabolism; Middle Aged; Neoplasms - drug therapy; Phenotype; Polymorphism; Polymorphism, Genetic; Roma; Roma - genetics; Taxane; Taxoids - metabolism; Taxoids - therapeutic use; Tubulin Modulators - metabolism; Tubulin Modulators - therapeutic use; Young Adult; Hungary; CYP2C8; Roma; CYP1B1; Hungarian; Taxane; Metabolism; CYP3A5; Polymorphism

Taxanes are widely used microtubule-stabilizing chemotherapeutic agents in the treatment of cancers. Several cytochrome P450 gene variants have been proven to influence taxane metabolism and therapy. The purpose of this work was to determine the distribution of genetic variations of CYP1B1, CYP2C8 a...