Reactive Palladium–Ligand Complexes for 11C-Carbonylation at Ambient Pressure: A Breakthrough in Carbon-11 Chemistry

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 16; no. 7; p. 955
• Main Authors: Dahl, Kenneth, Lindberg, Anton, Vasdev, Neil, Schou, Magnus
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 03.07.2023; MDPI
• Subjects: Automation; Carbon dioxide; Carbon monoxide; carbon-11; carbonylation; Labeling; Ligands; Molybdenum; radiochemistry; radiopharmaceuticals; Reagents; Review; Xantphos

The Pd–Xantphos-mediated 11C-carbonylation protocol (also known as the “Xantphos- method”), due to its simplistic and convenient nature, has facilitated researchers in meeting a longstanding need for preparing 11C-carbonyl-labeled radiopharmaceuticals at ambient pressure for positron emission tomogr...