Effect of Paricalcitol on Left Ventricular Mass and Function in CKD—The OPERA Trial

• Published in: Journal of the American Society of Nephrology Vol. 25; no. 1; pp. 175 - 186
• Main Authors: Wang, Angela Yee-Moon, Fang, Fang, Chan, John, Wen, Yue-Yi, Qing, Shang, Chan, Iris Hiu-Shuen, Lo, Gladys, Lai, Kar-Neng, Lo, Wai-Kei, Lam, Christopher Wai-Kei, Yu, Cheuk-Man
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society of Nephrology 01.01.2014
• Subjects: Aged; Alkaline Phosphatase - blood; Biological and medical sciences; Blood Pressure - drug effects; Clinical Research; Double-Blind Method; Echocardiography; Ergocalciferols - adverse effects; Ergocalciferols - therapeutic use; Female; Humans; Hypercalcemia - chemically induced; Hypertrophy, Left Ventricular - drug therapy; Hypertrophy, Left Ventricular - etiology; Hypertrophy, Left Ventricular - pathology; Kidneys; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Parathyroid Hormone - blood; Prospective Studies; Renal failure; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - drug therapy; Renal Insufficiency, Chronic - pathology; Urinary system involvement in other diseases. Miscellaneous; Ventricular Dysfunction, Left - drug therapy; Ventricular Dysfunction, Left - etiology; Ventricular Dysfunction, Left - physiopathology; Kidney disease; Agonist; Nephrology; Urinary system disease; Chronic kidney disease; Urology; Mass; Vitamin D; Analog; Renal failure; Paricalcitol; Clinical trial; Left ventricle performance

Vitamin D seems to protect against cardiovascular disease, but the reported effects of vitamin D on patient outcomes in CKD are controversial. We conducted a prospective, double blind, randomized, placebo-controlled trial to determine whether oral activated vitamin D reduces left ventricular (LV) ma...