Changes in serum thioredoxin among individuals chronically exposed to arsenic in drinking water

• Published in: Toxicology and applied pharmacology Vol. 259; no. 1; pp. 124 - 132
• Main Authors: Li, Yuanyuan, Gao, Yanhui, Zhao, Lijun, Wei, Yudan, Feng, Hongqi, Wang, Cheng, Wei, Wei, Ding, Yunpeng, Sun, Dianjun
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 15.02.2012; Elsevier
• Subjects: 60 APPLIED LIFE SCIENCES; ABSORPTION SPECTROSCOPY; Adult; Aged; ARSENIC; Arsenic (As); Arsenic Poisoning - blood; Arsenic Poisoning - epidemiology; Arsenic Poisoning - etiology; Arsenic Poisoning - urine; Arsenicals - adverse effects; Arsenicals - analysis; Arsenicals - urine; atomic absorption spectrometry; Biological and medical sciences; BIOLOGICAL MARKERS; Biomarkers; Biomarkers - blood; blood serum; Carcinogenesis, carcinogens and anticarcinogens; Chemical agents; Chemical and industrial products toxicology. Toxic occupational diseases; CHINA; China - epidemiology; chronic exposure; DAMAGE; DRINKING WATER; Drinking Water - analysis; Drinking Water - standards; Environmental Exposure - adverse effects; Environmental Exposure - analysis; ENZYME IMMUNOASSAY; enzyme-linked immunosorbent assay; Female; Humans; hydrides; INTAKE; Male; Medical sciences; Metals and various inorganic compounds; Middle Aged; OXIDATION; Oxidative damage; patients; POISONING; Serum thioredoxin (TRX); SKIN; skin lesions; SYMPTOMS; Thioredoxins - blood; Time Factors; TOXICITY; Toxicology; Tumors; Water Pollutants, Chemical - analysis; Water Pollutants, Chemical - toxicity; Water Pollutants, Chemical - urine; China; Biomarkers; Serum thioredoxin (TRX); Oxidative damage; Arsenic (As); Human; Drinking water; Biological fluid; Oxidative stress; Arsenic; Biological marker; Thioredoxin; Carcinogen; Chronic; Serum

It is well known that oxidative damage plays a key role in the development of chronic arsenicosis. There is a complex set of mechanisms of redox cycling in vivo to protect cells from the damage. In this study, we examined the differences in the levels of serum thioredoxin1 (TRX1) among individuals e...