Antiproteinuric effects of angiotensin receptor blockers: telmisartan versus valsartan in hypertensive patients with type 2 diabetes mellitus and overt nephropathy

• Published in: Nephrology, dialysis, transplantation Vol. 23; no. 10; pp. 3174 - 3183
• Main Authors: Galle, Jan, Schwedhelm, Edzard, Pinnetti, Sabine, Böger, Rainer H., Wanner, Christoph
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2008; Oxford Publishing Limited (England)
• Subjects: Adult; Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Angiotensin II Type 1 Receptor Blockers - therapeutic use; angiotensin receptor blockers; Arginine - analogs & derivatives; Arginine - blood; Associated diseases and complications; Benzimidazoles - therapeutic use; Benzoates - therapeutic use; Biological and medical sciences; Blood Pressure - drug effects; C-Reactive Protein - metabolism; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes. Impaired glucose tolerance; Diabetic Nephropathies - complications; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - physiopathology; diabetic nephropathy; Dinoprost - analogs & derivatives; Dinoprost - urine; Double-Blind Method; Emergency and intensive care: renal failure. Dialysis management; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Humans; Hypertension - complications; Hypertension - drug therapy; Hypertension - physiopathology; Intensive care medicine; Male; Medical sciences; Middle Aged; Prospective Studies; proteinuria; Proteinuria - prevention & control; Renin-Angiotensin System - drug effects; Renin-Angiotensin System - physiology; telmisartan; Tetrazoles - therapeutic use; Valine - analogs & derivatives; Valine - therapeutic use; Valsartan; valsartan; angiotensin receptor blockers; telmisartan; proteinuria; diabetic nephropathy; Endocrinopathy; Type 2 diabetes; Imidazole derivatives; Tetrazole derivatives; Valsartan; Hemodialysis; Peptide hormone; Cardiovascular disease; Extrarenal dialysis; Octapeptide; Angiotensin II; Valine derivatives; Kidney disease; Human; Hypertension; Urinary system disease; Metabolic diseases; Telmisartan; Nephropathy; Benzimidazole derivatives; Biphenyl derivatives; Aminoacid; Renal failure; Antihypertensive agent; Sartan derivatives; Angiotensin antagonist; Comparative study; Proteinuria

Background. Renin–angiotensin system blockade reduces proteinuria and prevents nephropathy progression in patients with type 2 diabetes mellitus (T2D). Experimental evidence demonstrates that angiotensin receptor blockers (ARBs) possess anti-inflammatory potential, which might contribute to reducing...