Pancreatic β-cells respond to fuel pressure with an early metabolic switch

• Published in: Scientific reports Vol. 10; no. 1; p. 15413
• Main Authors: Malinowski, Ronja M., Ghiasi, Seyed M., Mandrup-Poulsen, Thomas, Meier, Sebastian, Lerche, Mathilde H., Ardenkjær-Larsen, Jan H., Jensen, Pernille R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.09.2020
• Subjects: 631/1647/320; 631/45; 692/163/2743/137; 692/53; Animals; Cell Line; Fatty Acids - metabolism; Glucose - metabolism; Humanities and Social Sciences; Insulin - metabolism; Insulin Secretion - physiology; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - physiology; Lipid Metabolism - physiology; Metabolic Networks and Pathways - physiology; Metabolomics - methods; multidisciplinary; Pressure; Pyruvic Acid - metabolism; Rats; Science; Science (multidisciplinary); Signal Transduction - physiology

Pancreatic β-cells become irreversibly damaged by long-term exposure to excessive glucose concentrations and lose their ability to carry out glucose stimulated insulin secretion (GSIS) upon damage. The β-cells are not able to control glucose uptake and they are therefore left vulnerable for endogeno...