Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease

• Published in: Kidney international Vol. 75; no. 9; pp. 976 - 981
• Main Authors: Ashby, Damien R., Gale, Daniel P., Busbridge, Mark, Murphy, Kevin G., Duncan, Neill D., Cairns, Tom D., Taube, David H., Bloom, Stephen R., Tam, Frederick W.K., Chapman, Richard S., Maxwell, Patrick H., Choi, Peter
• Format: Journal Article
• Language: English
• Published: Basingstoke Elsevier Inc 01.05.2009; Nature Publishing Group; Elsevier Limited
• Subjects: Adult; Aged; Aged, 80 and over; Anemia - metabolism; Antimicrobial Cationic Peptides - blood; Antimicrobial Cationic Peptides - drug effects; Biological and medical sciences; Case-Control Studies; Circadian Rhythm; dialysis; erythropoietin; Erythropoietin - pharmacology; Erythropoietin - therapeutic use; Female; ferritin; Ferritins - blood; Glomerular Filtration Rate; hepcidin; Hepcidins; Humans; iron; kidney disease; Kidney Diseases - blood; Kidney Diseases - drug therapy; Kidney Diseases - metabolism; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Radioimmunoassay; Recombinant Proteins; Renal failure; Young Adult; dialysis; iron; kidney disease; ferritin; hepcidin; erythropoietin; Kidney disease; Nephrology; Urinary system disease; Erythropoietin; Ferritin; Iron; Urology; Blood plasma; Nephropathy; Treatment; Polypeptide; Renal failure; Dialysis; Hepcidin

Hepcidin is a critical inhibitor of iron export from macrophages, enterocytes, and hepatocytes. Given that it is filtered and degraded by the kidney, its elevated levels in renal failure have been suggested to play a role in the disordered iron metabolism of uremia, including erythropoietin resistan...