Synthesis and in Vitro Evaluation of 5-closo- and 5-nido-Orthocarboranyluridines as Boron Carriers

• Published in: Bulletin of the Chemical Society of Japan Vol. 70; no. 12; pp. 3103 - 3110
• Main Authors: Imamura, Ken-ichiro, Yamamoto, Yoshinori
• Format: Journal Article
• Language: English
• Published: TOKYO The Chemical Society of Japan 01.12.1997; Chemical Soc Japan; Chemical Society of Japan
• Subjects: Chemistry; Chemistry, Multidisciplinary; Physical Sciences; Science & Technology; CANCER-CELLS; ACID RELATED-COMPOUNDS; P-BORONOPHENYLALANINE; ANALOGS; INVITRO; NEUTRON-CAPTURE THERAPY; BIOLOGICAL PROPERTIES; STEREOCHEMISTRY; GLYCOSYLATION; NUCLEOSIDE BASES

Sugar-part modified closo-carboranyluridines, 5-(o-carboran-1-yl)-2′,3′-dideoxy-3′-thiauridine 5 and 5-(o-carboran-1-yl)-2′,3′-dideoxy-2′α-phenylthiouridine 6, were synthesized. These newly synthesized closo-carboranyluridines, 5 and 6, and previously synthesized 5-(o-carboran-1-yl)uridine 1 were co...