Small molecule inhibitors of the fosfomycin resistance enzyme FosM from Mycobacterium abscessus

• Published in: Biochimica et biophysica acta. General subjects Vol. 1867; no. 10; p. 130444
• Main Authors: Chiasson, Skye, Smith, Tatum, Bello, Landon, Chandrika, Nishad Thamban, Green, Keith D., Garneau-Tsodikova, Sylvie, Thompson, Matthew K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2023
• Subjects: Anti-Bacterial Agents - pharmacology; Antimicrobial resistance; enzymes; ForM; Fosfomycin; Fosfomycin - pharmacology; Humans; Mycobacterium abscessus; Staphylococcal Infections; Staphylococcus aureus; Antimicrobial resistance; ForM; Mycobacterium abscessus; Fosfomycin

Fosfomycin is a safe broad-spectrum antibiotic that has not achieved widespread use because of the emergence of fosfomycin-modifying enzymes. Inhibition of fosfomycin-modifying enzymes could be used to help combat pathogens like Mycobacterium abscessus. Our previous work identified several inhibitor...