Regulation of the human relaxin genes H1 and H2 by steroid hormones

• Published in: Molecular and cellular endocrinology Vol. 219; no. 1; pp. 115 - 125
• Main Authors: Garibay-Tupas, Jermelina L, Okazaki, Kristie J, Tashima, Lily S, Yamamoto, Sandra, Bryant-Greenwood, Gillian D
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 30.04.2004
• Subjects: Amino Acid Motifs; Dexamethasone; Dexamethasone - pharmacology; Electrophoretic Mobility Shift Assay; Gene expression; Gene Expression Regulation; Glucocorticoids - pharmacology; Humans; JAR cells; Medroxyprogesterone acetate; Medroxyprogesterone Acetate - pharmacology; Progesterone - pharmacology; Promoter Regions, Genetic - drug effects; Protein Binding; Relaxin; Relaxin - genetics; RNA, Messenger - analysis; Transcription; Dexamethasone; Medroxyprogesterone acetate; Transcription; Gene expression; Relaxin; JAR cells

Relaxin, a peptide hormone important to the outcome of human pregnancy is expressed in a tissue specific manner as two genes known as relaxins H1 and H2, in addition to a third human relaxin H3, expressed primarily in the brain. The H1 and H2 genes are highly homologous, differentially expressed in...