Assessment of the Effects of Inhibition or Induction of CYP2C19 and CYP2C9 Enzymes, or Inhibition of OAT3, on the Pharmacokinetics of Abrocitinib and Its Metabolites in Healthy Individuals - Wang, Xiaoxing; Dowty, Martin E.; Wouters, Ann; Tatulych, Svitlana; Connell, Carol A.; Le, Vu H.; Tripathy, Sakambari; O’Gorman, Melissa T.; Winton, Jennifer A.; Yin, Natalie; Valdez, Hernan; Malhotra, Bimal K. (European journal of drug metabolism and pharmacokinetics, 2022)
Keywords: Adult; Area Under Curve; Biomedical and Life Sciences; Biomedicine; Clinical Trials, Phase I as Topic; Cytochrome P-450 CYP2C19 - metabolism; Cytochrome P-450 CYP2C9 - metabolism; Cytochrome P-450 Enzyme System - metabolism; Drug Interactions; Fluconazole - pharmacology; Fluvoxamine; Human Physiology; Humans; Medical Biochemistry; NCT; NCT03634345; NCT03637790; NCT03937258; Original; Original Research Article; Pharmaceutical Sciences/Technology; Pharmacology/Toxicology; Pharmacy; Probenecid; Pyrimidines; Rifampin; Sulfonamides