Proposals for uniform collection of biospecimens from neoadjuvant breast cancer clinical trials: timing and specimen types

• Published in: The lancet oncology Vol. 12; no. 12; pp. 1162 - 1168
• Main Authors: Loi, Sherene, MD, Symmans, W Fraser, Prof, Bartlett, John MS, Prof, Fumagalli, Debora, MD, Veer, Laura Van't, Prof, Forbes, John F, Prof, Bedard, Philippe, MD, Denkert, Carsten, MD, Zujewski, JoAnne, MD, Viale, Giuseppe, Prof, Pusztai, Lajos, Prof, Esserman, Laura J, Prof, Leyland-Jones, Brian R, Prof
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2011; Elsevier Limited
• Subjects: Biomarkers; Biopsy; Biopsy - standards; Breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - therapy; Cancer therapies; Clinical trials; Clinical Trials as Topic - standards; Female; Fixatives - standards; Formaldehyde - standards; Hematology, Oncology and Palliative Medicine; Humans; Molecular Diagnostic Techniques - standards; Neoadjuvant Therapy; Paraffin Embedding - standards; Patients; Practice Guidelines as Topic; Predictive Value of Tests; Specimen Handling - standards; Time Factors; Tissue Fixation - standards; Womens health

Summary In this Personal View, we outline proposals for uniform collection of biospecimens obtained in neoadjuvant breast cancer trials undertaken by the Breast International Group (BIG) and the National Cancer Institute-sponsored North American Breast Cancer Group (NABCG). These proposals aim to st...