Anticancer and chemosensitization effects of cannabidiol in 2D and 3D cultures of TNBC: involvement of GADD45α, integrin-α5, -β5, -β1, and autophagy

• Published in: Drug delivery and translational research Vol. 12; no. 11; pp. 2762 - 2777
• Main Authors: Surapaneni, Sunil Kumar, Patel, Nilkumar, Sun, Li, Kommineni, Nagavendra, Kalvala, Anil Kumar, Gebeyehu, Aragaw, Arthur, Peggy, Duke, Leanne C., Nimma, Ramesh, G Meckes, David, Singh, Mandip
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2022
• Subjects: Apoptosis; Autophagy; Beclin-1 - metabolism; Beclin-1 - pharmacology; Biomedical and Life Sciences; Biomedicine; Cannabidiol - pharmacology; Caspase 9 - metabolism; Caspase 9 - pharmacology; Cell Line, Tumor; Cell Proliferation; Doxorubicin - pharmacology; Fibronectins; Humans; Hydrogels; Integrin alpha5 - metabolism; Integrin alpha5 - pharmacology; Original Article; Pharmaceutical Sciences/Technology; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - metabolism; Vimentin - metabolism; Vimentin - pharmacology; Cannabidiol; TNBC; GADD45α; Doxorubicin; Autophagy; Integrins

To date, promising therapy for triple negative breast cancer (TNBC) remains a serious concern clinically because of poor prognosis, resistance, and recurrence. Herein, anti-cancer potential of synthetic cannabidiol (CBD; Purisys, GA; GMP grade) was explored either alone or as a chemosensitizer follo...