Drug resistance mechanisms and novel drug targets for tuberculosis therapy

• Published in: Journal of genetics and genomics Vol. 44; no. 1; pp. 21 - 37
• Main Authors: Islam, Md Mahmudul, Hameed, H.M. Adnan, Mugweru, Julius, Chhotaray, Chiranjibi, Wang, Changwei, Tan, Yaoju, Liu, Jianxiong, Li, Xinjie, Tan, Shouyong, Ojima, Iwao, Yew, Wing Wai, Nuermberger, Eric, Lamichhane, Gyanu, Zhang, Tianyu
• Format: Journal Article
• Language: English
• Published: China Elsevier Ltd 20.01.2017
• Subjects: Animals; Antitubercular Agents - pharmacology; Antitubercular Agents - therapeutic use; Drug Resistance, Bacterial - genetics; Drug target; Genomics; Humans; Mechanism; Molecular Targeted Therapy - methods; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - physiology; Resistance; Tuberculosis; Tuberculosis - drug therapy; Resistance; Drug target; Tuberculosis; Mycobacterium tuberculosis; Mechanism

Drug-resistant tuberculosis （TB） poses a significant challenge to the successful treatment and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era. New insights into the resistant mechanisms of anti-TB drugs have been provided. Better understa...