A CRISPR/Cas12a-responsive dual-aptamer DNA network for specific capture and controllable release of circulating tumor cells

• Published in: Chemical science (Cambridge) Vol. 13; no. 35; pp. 1395 - 145
• Main Authors: Wang, Dong-Xia, Wang, Jing, Wang, Ya-Xin, Ma, Jia-Yi, Liu, Bo, Tang, An-Na, Kong, De-Ming
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 14.09.2022; The Royal Society of Chemistry
• Subjects: Chemistry; CRISPR; Deoxyribonucleic acid; Diagnosis; DNA; Smart sensors; Tumors

The separation and detection of circulating tumor cells (CTCs) have a significant impact on clinical diagnosis and treatment by providing a predictive diagnosis of primary tumors and tumor metastasis. But the responsive release and downstream analysis of live CTCs will provide more valuable informat...