In Vivo Genome-Wide PGR Binding in Pregnant Human Myometrium Identifies Potential Regulators of Labor

• Published in: Reproductive sciences (Thousand Oaks, Calif.) Vol. 30; no. 2; pp. 544 - 559
• Main Authors: Dotts, Ariel J., Reiman, Derek, Yin, Ping, Kujawa, Stacy, Grobman, William A., Dai, Yang, Bulun, Serdar E.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2023
• Subjects: Embryology; Female; Genome-Wide Association Study; Humans; Labor, Obstetric - genetics; Labor, Obstetric - metabolism; Medicine; Medicine & Public Health; Myometrium - metabolism; Obstetrics/Perinatology/Midwifery; Polycomb Repressive Complex 1 - metabolism; Pregnancy; Progesterone - metabolism; Protein Binding; Reproductive Biology: Original; Reproductive Biology: Original Article; Reproductive Medicine; Human myometrial tissues; PGR; Labor; Transcriptome

  The alterations in myometrial biology during labor are not well understood. The myometrium is the contractile portion of the uterus and contributes to labor, a process that may be regulated by the steroid hormone progesterone. Thus, human myometrial tissues from term pregnant in-active-labor (TIL)...