Influences of age and pubertal status on number and intensity of perineuronal nets in the rat medial prefrontal cortex

• Published in: Brain structure & function Vol. 225; no. 8; pp. 2495 - 2507
• Main Authors: Drzewiecki, Carly M., Willing, Jari, Juraska, Janice M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2020
• Subjects: Biomedical and Life Sciences; Biomedicine; Cell Biology; Neurology; Neurosciences; Original Article; PNN; Stereology; Inhibition; White matter; Adolescent; Estrogen

The prefrontal cortex (PFC) is a late developing region of the cortex, and its protracted maturation during adolescence may confer a period of plasticity. Closure of critical, or sensitive, periods in sensory cortices coincides with perineuronal net (PNN) expression, leading to enhanced inhibitory f...