Association of MMP-8 with obesity, smoking and insulin resistance

• Published in: European journal of clinical investigation Vol. 46; no. 9; pp. 757 - 765
• Main Authors: Lauhio, Anneli, Färkkilä, Esa, Pietiläinen, Kirsi H., Åström, Pirjo, Winkelmann, Alina, Tervahartiala, Taina, Pirilä, Emma, Rissanen, Aila, Kaprio, Jaakko, Sorsa, Timo A., Salo, Tuula
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2016
• Subjects: Adult; Antigens, CD - metabolism; Case-Control Studies; Dipeptides - pharmacology; Doxycycline - pharmacology; Female; Humans; Hydroxamic Acids; In Vitro Techniques; Indoles - pharmacology; Insulin Resistance; Male; Matrix Metalloproteinase 13 - blood; Matrix Metalloproteinase 8 - blood; Matrix Metalloproteinase 8 - drug effects; Matrix Metalloproteinase 8 - metabolism; Matrix Metalloproteinase 9 - blood; Matrix Metalloproteinase Inhibitors - pharmacology; Medicin och hälsovetenskap; MMP-8; MMP-8 inhibitor; obesity; Obesity - blood; Overweight - blood; Receptor, Insulin - metabolism; smoking; Smoking - blood; therapy target; Tissue Inhibitor of Metalloproteinase-1 - blood; Twins, Dizygotic; Twins, Monozygotic; Young Adult; therapy target; MMP-8 inhibitor; Insulin resistance; MMP-8; obesity; smoking

Background Obesity has been recognized as a state of subclinical inflammation resulting in a loss of insulin receptors and decreased insulin sensitivity. We here studied in vivo the role of circulating matrix metalloproteinase‐8 (MMP‐8) among young healthy twin adults. Also, in vitro analysis of the...