Antihypertensive Therapy and Cardiovascular Risk: Are All Antihypertensives Equal?
The lack of success of antihypertensive drug therapy in decreasing cardiovascular events has caused close examination of the influence of antihypertensive drugs on cardiac risk factors. Striking differences exist in the pharmacological profiles of antihypertensive drug classes and subclasses as well...
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Published in | Hypertension (Dallas, Tex. 1979) Vol. 19; no. 1 Suppl I; pp. I-124 - I-129 |
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Main Author | |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Philadelphia, PA
American Heart Association, Inc
01.01.1992
Hagerstown, MD Lippincott |
Subjects | |
Online Access | Get full text |
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Abstract | The lack of success of antihypertensive drug therapy in decreasing cardiovascular events has caused close examination of the influence of antihypertensive drugs on cardiac risk factors. Striking differences exist in the pharmacological profiles of antihypertensive drug classes and subclasses as well as in the influences of the drugs on electrolyte, lipid, and glucose metabolism. Differences also exist in the effects of the drugs on left ventricular hypertrophy. These differences in the effects of antihypertensive drugs on cardiac risk factors may assist in explaining the lack of a favorable effect on cardiovascular events in previous clinical trials. However, prospective trials are necessary to demonstrate that treatment of hypertension with drugs that have a more favorable effect on cardiac risk factors will reduce cardiac events (i.e., myocardial infarction, heart failure, and sudden death). |
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AbstractList | Abstract only
The lack of success of antihypertensive drug therapy in decreasing cardiovascular events has caused close examination of the influence of antihypertensive drugs on cardiac risk factors. Striking differences exist in the pharmacological profiles of antihypertensive drug classes and subclasses as well as in the influences of the drugs on electrolyte, lipid, and glucose metabolism. Differences also exist in the effects of the drugs on left ventricular hypertrophy. These differences in the effects of antihypertensive drugs on cardiac risk factors may assist in explaining the lack of a favorable effect on cardiovascular events in previous clinical trials. However, prospective trials are necessary to demonstrate that treatment of hypertension with drugs that have a more favorable effect on cardiac risk factors will reduce cardiac events (i.e., myocardial infarction, heart failure, and sudden death). The lack of success of antihypertensive drug therapy in decreasing cardiovascular events has caused close examination of the influence of antihypertensive drugs on cardiac risk factors. Striking differences exist in the pharmacological profiles of antihypertensive drug classes and subclasses as well as in the influences of the drugs on electrolyte, lipid, and glucose metabolism. Differences also exist in the effects of the drugs on left ventricular hypertrophy. These differences in the effects of antihypertensive drugs on cardiac risk factors may assist in explaining the lack of a favorable effect on cardiovascular events in previous clinical trials. However, prospective trials are necessary to demonstrate that treatment of hypertension with drugs that have a more favorable effect on cardiac risk factors will reduce cardiac events (i.e., myocardial infarction, heart failure, and sudden death). |
Author | Giles, Thomas D |
AuthorAffiliation | Cardiovascular Research Laboratory, Department of Medicine, Tulane University School of Medicine, New Orleans, La |
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SubjectTerms | Antihypertensive agents Antihypertensive Agents - therapeutic use Biological and medical sciences Cardiovascular Diseases - complications Cardiovascular Diseases - drug therapy Cardiovascular Diseases - epidemiology Cardiovascular system Humans Hypertension - complications Hypertension - drug therapy Medical sciences Morbidity Pharmacology. Drug treatments Risk Factors United States - epidemiology |
Title | Antihypertensive Therapy and Cardiovascular Risk: Are All Antihypertensives Equal? |
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