Asymmetric autocatalysis and the origin of chiral homogeneity in organic compounds

• Published in: Chemical record Vol. 1; no. 4; pp. 321 - 332
• Main Authors: Soai, Kenso, Sato, Itaru, Shibata, Takanori
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 2001
• Subjects: Aldehydes - chemistry; amplification; asymmetric autocatalysis; asymmetric synthesis; Catalysis; circularly polarized light; dialkylzinc; Feedback, Physiological; Models, Molecular; Molecular Mimicry; origin of chirality; Pyrimidines - chemistry; quartz; Stereoisomerism; Zinc - chemistry

The discovery and development of asymmetric autocatalysis, in which the structures of the chiral catalyst and the chiral product are the same, are described. Chiral 5‐pyrimidyl, 3‐quinolyl, and 5‐carbamoyl‐3‐pyridyl alkanols act as highly enantioselective asymmetric autocatalysts in the enantioselec...