A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway

• Published in: Journal of experimental & clinical cancer research Vol. 38; no. 1; pp. 89 - 17
• Main Authors: Huang, Wei-Chieh, Jang, Te-Hsuan, Tung, Shiao-Lin, Yen, Tzu-Chen, Chan, Shih-Hsuan, Wang, Lu-Hai
• Format: Journal Article
• Language: English
• Published: England BioMed Central 19.02.2019; BMC
• Subjects: C-met; ETS homologous factor; Keratin 16; miR-365-3p; Oral squamous cell carcinoma; β5-integrin; β5-integrin; C-met; Chemoresistance; Keratin 16; miR-365-3p; ETS homologous factor; Oral squamous cell carcinoma

Targeting the c-Met signaling pathway has become a therapeutic strategy in multiple types of cancer. We unveiled a novel c-Met regulating mechanism that could be applied as a modality for oral squamous cell carcinoma (OSCC) therapy. Upregulation of keratin 16 (KRT16) was found by comparing isogenic...