Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects

• Published in: British journal of clinical pharmacology Vol. 58; no. 3; pp. 332 - 335
• Main Authors: Yang, Y. S., Wong, L. P., Lee, T. C., Mustafa, A. M., Mohamed, Z., Lang, Chim C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.09.2004; Blackwell Science; Blackwell Science Inc
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Aryl Hydrocarbon Hydroxylases - genetics; Biological and medical sciences; Cytochrome P-450 CYP2C19; Cytochrome P450 2C19 polymorphism Malaysian; Female; Gene Frequency; General pharmacology; Humans; Malaysia; Male; Medical sciences; Mixed Function Oxygenases - genetics; Omeprazole - analogs & derivatives; Omeprazole - metabolism; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Phenotype; Polymerase Chain Reaction; Polymorphism, Genetic - genetics; Short Reports; Asia; Malaysia; Human; Cytochrome P450 2C19 polymorphism Malaysian; Healthy subject; Cytochrome P450; Genetics; Ethnic group; Polymorphism

Aims Impaired S‐mephenytoin 4′‐hydroxylation is a well‐described genetic polymorphism affecting drug metabolism in humans. Although ethnic differences in its distribution of polymorphism has been described, it is not known whether there is an ethnic heterogeneity of the structure and expression of t...