Identification of hepatitis C virus genotype 6 in Korean patients by analysis of 5' untranslated region using a matrix assisted laser desorption/ionization time of flight-based assay, restriction fragment mass polymorphism

• Published in: Journal of medical virology Vol. 80; no. 10; pp. 1712 - 1719
• Main Authors: Oh, Heung-Bum, Kim, Soo-Ok, Cha, Choong-Hwan, Hong, Sun Pyo, Folk, William R, Kim, Kang Mo, Suh, Dong Jin
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2008; Wiley-Liss
• Subjects: 5' Untranslated Regions - genetics; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents - therapeutic use; Biological and medical sciences; Child; Female; Fundamental and applied biological sciences. Psychology; genotype; Hepacivirus - classification; Hepacivirus - genetics; Hepacivirus - isolation & purification; Hepatitis C - drug therapy; Hepatitis C - epidemiology; Hepatitis C - virology; Hepatitis C virus; Human viral diseases; Humans; Infectious diseases; Interferons - therapeutic use; Korea; Korea - epidemiology; Male; matrix-assisted laser desorption-ionization mass spectrometry; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Polymorphism, Genetic; Prognosis; Ribavirin - therapeutic use; Sequence Analysis, RNA - methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods; Viral diseases; Virology; Asia; Korea; Virus; Human; Genotype; Identification; Matrix assisted laser desorption ionization; Flaviviridae; Hepatitis C virus; Hepacivirus; Polymorphism; Korea; matrix-assisted laser desorption-ionization mass spectrometry

Previous surveys of the prevalence of hepatitis C virus (HCV) in Korea have identified types 1 and 2, but little has been said of other genotypes and viral subtypes. In this study, HCV genotypes in Korea were investigated using Restriction Fragment Mass Polymorphism (RFMP) assay, a sensitive and spe...