Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRI

• Published in: Medical physics (Lancaster) Vol. 32; no. 4; p. 1128
• Main Authors: Choe, Regine, Corlu, Alper, Lee, Kijoon, Durduran, Turgut, Konecky, Soren D, Grosicka-Koptyra, Monika, Arridge, Simon R, Czerniecki, Brian J, Fraker, Douglas L, DeMichele, Angela, Chance, Britton, Rosen, Mark A, Yodh, Arjun G
• Format: Journal Article
• Language: English
• Published: United States 01.04.2005
• Subjects: Adult; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Carcinoma, Ductal, Breast - drug therapy; Carcinoma, Ductal, Breast - pathology; Chemotherapy, Adjuvant - methods; Female; Hemoglobins - chemistry; Hemoglobins - metabolism; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Lasers; Magnetic Resonance Imaging - methods; Mammography - methods; Mastectomy; Models, Statistical; Oxygen - metabolism; Spectrophotometry, Infrared; Tomography, Optical - methods

We employ diffuse optical tomography (DOT) to track treatment progress in a female subject presenting with locally advanced invasive carcinoma of the breast during neoadjuvant chemotherapy. Three-dimensional images of total hemoglobin concentration and scattering identified the tumor. Our measuremen...