Modulation of heart fibroblast migration and collagen gel contraction by IGF-I

• Published in: Cell adhesion and communication Vol. 7; no. 6; p. 513
• Main Authors: Kanekar, S, Borg, T K, Terracio, L, Carver, W
• Format: Journal Article
• Language: English
• Published: Switzerland 2000
• Subjects: Animals; Animals, Newborn; Antigens, CD - biosynthesis; Antigens, CD - metabolism; Cell Adhesion - drug effects; Cell Movement - drug effects; Chromones - pharmacology; Collagen; Enzyme Inhibitors - pharmacology; Extracellular Matrix - enzymology; Female; Fibroblasts - cytology; Fibroblasts - enzymology; Flavonoids - pharmacology; Gels; Insulin-Like Growth Factor I - pharmacology; Integrin alphaV; Integrin beta1 - biosynthesis; Integrin beta1 - metabolism; Matrix Metalloproteinases - metabolism; Morpholines - pharmacology; Myocardium - cytology; Myocardium - enzymology; Pregnancy; Protein-Tyrosine Kinases - metabolism; Rats; Rats, Sprague-Dawley; Receptors, Vitronectin - biosynthesis; Receptors, Vitronectin - metabolism; Signal Transduction - drug effects; Signal Transduction - physiology

Dynamic interactions between cells and the extracellular matrix are essential in the regulation of a number of cellular processes including migration, adhesion, proliferation and differentiation. A variety of factors have been identified which modulate these interactions including transforming growt...