The density and spatial distribution of gabaergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia

• Published in: Biological psychiatry (1969) Vol. 51; no. 5; pp. 377 - 386
• Main Authors: Cotter, David, Landau, Sabine, Beasley, Clare, Stevenson, Robert, Chana, Gursharon, MacMillan, Laura, Everall, Ian
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2002; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; anterior cingulate cortex; Biological and medical sciences; bipolar disorder; Bipolar Disorder - pathology; calcium binding proteins; Calcium-Binding Proteins - metabolism; Cell Count; Depressive Disorder, Major - pathology; Female; gamma-Aminobutyric Acid - metabolism; Gyrus Cinguli - pathology; Humans; Male; Medical sciences; Middle Aged; Miscellaneous; Mood disorders; morphometry; Neurons - pathology; Postmortem; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - pathology; bipolar disorder; morphometry; schizophrenia; calcium binding proteins; anterior cingulate cortex; Postmortem; Mood disorder; Human; Calcium; Central nervous system; Anterior; Schizophrenia; Depression; Exploration; Bipolar disorder; Density distribution; Inorganic element; Psychosis; Binding protein; Spatial distribution; Cingulate cortex; Volume; GABA; Brain (vertebrata); Gabaergic neuron

Background: There is strong evidence for the presence of a deficit in cortical γ aminobutyric acid (GABA) neurotransmission in schizophrenia. In this investigation we have used the calcium binding proteins (CBPs) parvalbumin (PV), calretinin (CR), and calbindin-D28K (CB) as markers of these neuronal...