Activation of cell adhesion and migration is an early event of platelet-rich plasma (PRP)-dependent stimulation of human adipose-derived stem/stromal cells

• Published in: Human Cell Vol. 37; no. 1; pp. 181 - 192
• Main Authors: Michika, Fukui, Fangyuan, Lai, Masakatsu, Hihara, Toshihito, Mitsui, Yuki, Matsuoka, Zhongxin, Sun, Sakurako, Kunieda, Shigeru, Taketani, Tokifumi, Odaka, Kazu, Okuma, Natsuko, Kakudo
• Format: Journal Article
• Language: English
• Published: Singapore Springer Science and Business Media LLC 01.01.2024; Springer Nature Singapore; Springer Nature B.V
• Subjects: Actin; AKT protein; Biomedical and Life Sciences; Cell activation; Cell Adhesion; Cell adhesion & migration; Cell Biology; Cell migration; Cell proliferation; Cell Proliferation - physiology; Cell therapy; Extracellular signal-regulated kinase; Gynecology; Humans; Imatinib; Life Sciences; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Oncology; Paxillin; Paxillin - metabolism; Platelet-derived growth factor; Platelet-Rich Plasma - metabolism; Protein-tyrosine kinase receptors; Proto-Oncogene Proteins c-akt - metabolism; Regenerative medicine; Reproductive Medicine; Research Article; RhoA protein; Signal transduction; Stem Cells; Stromal cells; Surgery; Wound healing; Human adipose-derived stem/stromal cells (hASCs); Signal network; Platelet-rich plasma (PRP); Cell migration

Stem cell therapy is a promising treatment in regenerative medicine. Human adipose-derived stem/stromal cells (hASCs), a type of mesenchymal stem cell, are easy to harvest. In plastic and aesthetic surgery, hASC may be applied in the treatment of fat grafting, wound healing, and scar remodeling. Pla...