The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function

• Published in: Thrombosis research Vol. 106; no. 4; pp. 191 - 197
• Main Authors: Pearson, Debra A, Paglieroni, Teresa G, Rein, Dietrich, Wun, Ted, Schramm, Derek D, Wang, Janice F, Holt, Roberta R, Gosselin, Robert, Schmitz, Harold H, Keen, Carl L
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 15.05.2002; Elsevier Science
• Subjects: Adult; Antibodies, Monoclonal; Aspirin; Aspirin - pharmacology; Biological and medical sciences; Blood Coagulation Tests; Cacao; Catechin - blood; Catechin - pharmacokinetics; Cocoa flavonoids; Cross-Over Studies; Female; Flavonoids - pharmacology; GPIIb/IIIa complex; Hematologic and hematopoietic diseases; Humans; Male; Medical sciences; Middle Aged; P-selectin; Platelet activation; Platelet Activation - drug effects; Platelet diseases and coagulopathies; Platelet function; Platelet Glycoprotein GPIIb-IIIa Complex - analysis; Platelet Glycoprotein GPIIb-IIIa Complex - immunology; PFA-100; Aspirin; Platelet activation; CEPI; vWF; GPIIb/IIIa complex; GPIIb/IIIa-act; cocoa; ASA; Cocoa flavonoids; CVD; ASA+cocoa; CADP; Platelet function; RM ANOVA; P-selectin; Human; Glycoprotein IIbIIIa; Cell adhesion molecule; Cardiovascular disease; Activation; Acetylsalicylic acid; Cocoa; Flavonoid; Thrombosis; Biological activity; Feeding; Vascular disease; Prevention; P Selectin; Platelet; Diet; Comparative study

Background: Flavanols modulate platelet function in vitro, but less is known of their in vivo effects and how they compare to pharmacological platelet inhibitors. We investigated the effect of a flavanol-rich cocoa beverage (897 mg/ml) in combination with and in comparison to aspirin on platelet fun...