Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring
Aims/hypothesis Vitamin D deficiency during the fetal period or infancy is one of the suggested environmental factors for type 1 diabetes and for its increasing incidence. To test this hypothesis we compared serum 25-hydroxyvitamin D (25(OH)D) levels during early pregnancy in mothers of children who...
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Published in | Diabetologia Vol. 55; no. 5; pp. 1291 - 1294 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer-Verlag
01.05.2012
Springer Springer Nature B.V |
Subjects | |
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Abstract | Aims/hypothesis
Vitamin D deficiency during the fetal period or infancy is one of the suggested environmental factors for type 1 diabetes and for its increasing incidence. To test this hypothesis we compared serum 25-hydroxyvitamin D (25(OH)D) levels during early pregnancy in mothers of children who subsequently developed type 1 diabetes (case mothers) with mothers of non-diabetic healthy children (control mothers) of the same age.
Methods
Children with type 1 diabetes were identified from the nationwide prescription register. 25(OH)D concentration was measured from serum samples collected during the first trimester of pregnancy from all Finnish women (Finnish Maternity Cohort). A total of 343 case mothers and 343 control mothers were included in the study. Samples were collected throughout the year. Samples from case and control mothers were matched on the day of collection.
Results
Mean 25(OH)D levels in case mothers (43.9 nmol/l) and control mothers (43.7 nmol/l) were not different. Of all mothers, 481 (70.1%) were vitamin D-deficient or -insufficient.
Conclusions/interpretation
No difference was found in serum 25(OH)D concentrations during first trimester of pregnancy between mothers whose children later on developed type 1 diabetes, and mothers of non-diabetic ‘ healthy’ children of the same age. It is difficult to detect possible effects of mothers’ vitamin D deficiency during early pregnancy on the development of type 1 diabetes in the offspring in this population, as such a large proportion of mothers were vitamin D-deficient or -insufficient. |
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AbstractList | Aims/hypothesis
Vitamin D deficiency during the fetal period or infancy is one of the suggested environmental factors for type 1 diabetes and for its increasing incidence. To test this hypothesis we compared serum 25-hydroxyvitamin D (25(OH)D) levels during early pregnancy in mothers of children who subsequently developed type 1 diabetes (case mothers) with mothers of non-diabetic healthy children (control mothers) of the same age.
Methods
Children with type 1 diabetes were identified from the nationwide prescription register. 25(OH)D concentration was measured from serum samples collected during the first trimester of pregnancy from all Finnish women (Finnish Maternity Cohort). A total of 343 case mothers and 343 control mothers were included in the study. Samples were collected throughout the year. Samples from case and control mothers were matched on the day of collection.
Results
Mean 25(OH)D levels in case mothers (43.9 nmol/l) and control mothers (43.7 nmol/l) were not different. Of all mothers, 481 (70.1%) were vitamin D-deficient or -insufficient.
Conclusions/interpretation
No difference was found in serum 25(OH)D concentrations during first trimester of pregnancy between mothers whose children later on developed type 1 diabetes, and mothers of non-diabetic ‘ healthy’ children of the same age. It is difficult to detect possible effects of mothers’ vitamin D deficiency during early pregnancy on the development of type 1 diabetes in the offspring in this population, as such a large proportion of mothers were vitamin D-deficient or -insufficient. Vitamin D deficiency during the fetal period or infancy is one of the suggested environmental factors for type 1 diabetes and for its increasing incidence. To test this hypothesis we compared serum 25-hydroxyvitamin D (25(OH)D) levels during early pregnancy in mothers of children who subsequently developed type 1 diabetes (case mothers) with mothers of non-diabetic healthy children (control mothers) of the same age. Children with type 1 diabetes were identified from the nationwide prescription register. 25(OH)D concentration was measured from serum samples collected during the first trimester of pregnancy from all Finnish women (Finnish Maternity Cohort). A total of 343 case mothers and 343 control mothers were included in the study. Samples were collected throughout the year. Samples from case and control mothers were matched on the day of collection. Mean 25(OH)D levels in case mothers (43.9 nmol/l) and control mothers (43.7 nmol/l) were not different. Of all mothers, 481 (70.1%) were vitamin D-deficient or -insufficient. No difference was found in serum 25(OH)D concentrations during first trimester of pregnancy between mothers whose children later on developed type 1 diabetes, and mothers of non-diabetic ' healthy' children of the same age. It is difficult to detect possible effects of mothers' vitamin D deficiency during early pregnancy on the development of type 1 diabetes in the offspring in this population, as such a large proportion of mothers were vitamin D-deficient or -insufficient.[PUBLICATION ABSTRACT] Vitamin D deficiency during the fetal period or infancy is one of the suggested environmental factors for type 1 diabetes and for its increasing incidence. To test this hypothesis we compared serum 25-hydroxyvitamin D (25(OH)D) levels during early pregnancy in mothers of children who subsequently developed type 1 diabetes (case mothers) with mothers of non-diabetic healthy children (control mothers) of the same age. Children with type 1 diabetes were identified from the nationwide prescription register. 25(OH)D concentration was measured from serum samples collected during the first trimester of pregnancy from all Finnish women (Finnish Maternity Cohort). A total of 343 case mothers and 343 control mothers were included in the study. Samples were collected throughout the year. Samples from case and control mothers were matched on the day of collection. Mean 25(OH)D levels in case mothers (43.9 nmol/l) and control mothers (43.7 nmol/l) were not different. Of all mothers, 481 (70.1%) were vitamin D-deficient or -insufficient. No difference was found in serum 25(OH)D concentrations during first trimester of pregnancy between mothers whose children later on developed type 1 diabetes, and mothers of non-diabetic ' healthy' children of the same age. It is difficult to detect possible effects of mothers' vitamin D deficiency during early pregnancy on the development of type 1 diabetes in the offspring in this population, as such a large proportion of mothers were vitamin D-deficient or -insufficient. |
Author | Koskela, P. Miettinen, M. E. Kinnunen, L. Tuomilehto, J. Reinert, L. Surcel, H.-M. Lamberg-Allardt, C. Harjutsalo, V. |
Author_xml | – sequence: 1 givenname: M. E. surname: Miettinen fullname: Miettinen, M. E. email: maija.miettinen@thl.fi organization: Department of Public Health, University of Helsinki, Diabetes Prevention Unit, National Institute for Health and Welfare – sequence: 2 givenname: L. surname: Reinert fullname: Reinert, L. organization: Diabetes Prevention Unit, National Institute for Health and Welfare – sequence: 3 givenname: L. surname: Kinnunen fullname: Kinnunen, L. organization: Diabetes Prevention Unit, National Institute for Health and Welfare – sequence: 4 givenname: V. surname: Harjutsalo fullname: Harjutsalo, V. organization: Diabetes Prevention Unit, National Institute for Health and Welfare, Folkhälsan Institute of Genetics, Folkhälsan Research Centre, Biomedicum Helsinki, Division of Nephrology, Department of Medicine, Helsinki University Central Hospital – sequence: 5 givenname: P. surname: Koskela fullname: Koskela, P. organization: Child and Adolescent Health and Welfare Unit, National Institute for Health and Welfare – sequence: 6 givenname: H.-M. surname: Surcel fullname: Surcel, H.-M. organization: Child and Adolescent Health and Welfare Unit, National Institute for Health and Welfare – sequence: 7 givenname: C. surname: Lamberg-Allardt fullname: Lamberg-Allardt, C. organization: Calcium Research Unit, Department of Food and Environmental Sciences, University of Helsinki – sequence: 8 givenname: J. surname: Tuomilehto fullname: Tuomilehto, J. organization: Department of Public Health, University of Helsinki, Diabetes Prevention Unit, National Institute for Health and Welfare, South Ostrobothnia Central Hospital |
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Cites_doi | 10.1007/s00125-010-1734-8 10.1007/BF00400854 10.1007/s001250051112 10.1007/s00125-011-2278-2 10.1016/S0140-6736(08)60765-5 10.1007/s001250051499 10.1016/S0140-6736(01)06580-1 10.1016/j.bone.2009.03.659 10.1210/jc.2009-1391 10.1111/j.1463-1326.2010.01211.x 10.1111/j.1399-5448.2006.00223.x 10.1093/ajcn/84.1.18 10.1093/ajcn/78.6.1128 |
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Keywords | Pregnancy Vitamin D Type 1 diabetes 25-Hydroxyvitamin D Endocrinopathy Micronutrient Immunopathology Risk factor Autoimmune disease Serum |
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References | (CR4) 1999; 42 Stene, Ulriksen, Magnus, Joner (CR9) 2000; 43 Bischoff-Ferrari, Giovannucci, Willett, Dietrich, Dawson-Hughes (CR13) 2006; 84 Tuomilehto, Lounamaa, Tuomilehto-Wolf (CR14) 1992; 35 Kauppi, Impivaara, Mäki (CR3) 2009; 45 Hyppönen, Läärä, Reunanen, Järvelin, Virtanen (CR5) 2001; 358 Brekke, Ludvigsson (CR7) 2007; 8 Marjamäki, Niinistö, Kenward (CR10) 2010; 53 Simpson, Brady, Yin (CR8) 2011; 54 (CR11) 2004 (CR12) 2011 Stene, Joner (CR6) 2003; 78 Viljakainen, Saarnio, Hytinantti (CR15) 2010; 95 Hyppönen (CR1) 2010; 12 Harjutsalo, Sjöberg, Tuomilehto (CR2) 2008; 371 20649624 - Diabetes Obes Metab. 2010 Sep;12(9):737-43 11705562 - Lancet. 2001 Nov 3;358(9292):1500-3 21858504 - Diabetologia. 2011 Nov;54(11):2779-88 16825677 - Am J Clin Nutr. 2006 Jul;84(1):18-28 17341286 - Pediatr Diabetes. 2007 Feb;8(1):11-4 18502302 - Lancet. 2008 May 24;371(9626):1777-82 19328875 - Bone. 2009 Jul;45(1):119-24 20139235 - J Clin Endocrinol Metab. 2010 Apr;95(4):1749-57 20369220 - Diabetologia. 2010 Aug;53(8):1599-607 10027578 - Diabetologia. 1999 Jan;42(1):51-4 14668274 - Am J Clin Nutr. 2003 Dec;78(6):1128-34 1541383 - Diabetologia. 1992 Jan;35(1):70-6 11043854 - Diabetologia. 2000 Sep;43(9):1093-8 HA Bischoff-Ferrari (2458_CR13) 2006; 84 E Hyppönen (2458_CR5) 2001; 358 LC Stene (2458_CR6) 2003; 78 LC Stene (2458_CR9) 2000; 43 M Kauppi (2458_CR3) 2009; 45 EURODIAB Substudy 2 Study Group (2458_CR4) 1999; 42 J Tuomilehto (2458_CR14) 1992; 35 Institute of Medicine, Food and Nutrition Board (2458_CR12) 2011 HT Viljakainen (2458_CR15) 2010; 95 M Simpson (2458_CR8) 2011; 54 L Marjamäki (2458_CR10) 2010; 53 V Harjutsalo (2458_CR2) 2008; 371 HK Brekke (2458_CR7) 2007; 8 Nordic Council of Ministers (2458_CR11) 2004 E Hyppönen (2458_CR1) 2010; 12 |
References_xml | – volume: 53 start-page: 1599 issue: 8 year: 2010 end-page: 1607 ident: CR10 article-title: Maternal intake of vitamin D during pregnancy and risk of advanced beta cell autoimmunity and type 1 diabetes in offspring publication-title: Diabetologia doi: 10.1007/s00125-010-1734-8 contributor: fullname: Kenward – year: 2004 ident: CR11 publication-title: Nordic nutrition recommendations 2004. Integrating nutrition and physical activity – volume: 78 start-page: 1128 issue: 6 year: 2003 end-page: 1134 ident: CR6 article-title: Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case–control study publication-title: Am J Clin Nutr contributor: fullname: Joner – volume: 35 start-page: 70 year: 1992 end-page: 76 ident: CR14 article-title: Epidemiology of childhood diabetes mellitus in Finland—background of a nationwide study of type 1 (insulin-dependent) diabetes mellitus. The Childhood Diabetes in Finland (DiMe) Study Group publication-title: Diabetologia doi: 10.1007/BF00400854 contributor: fullname: Tuomilehto-Wolf – volume: 42 start-page: 51 year: 1999 end-page: 54 ident: CR4 article-title: Vitamin D supplement in early childhood and risk for type 1 (insulin-dependent) diabetes mellitus publication-title: Diabetologia doi: 10.1007/s001250051112 – volume: 54 start-page: 2779 issue: 11 year: 2011 end-page: 2788 ident: CR8 article-title: No association of vitamin D intake or 25-hydroxyvitamin D levels in childhood with risk of islet autoimmunity and type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY) publication-title: Diabetologia doi: 10.1007/s00125-011-2278-2 contributor: fullname: Yin – volume: 371 start-page: 1777 issue: 9626 year: 2008 end-page: 1782 ident: CR2 article-title: Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study publication-title: Lancet doi: 10.1016/S0140-6736(08)60765-5 contributor: fullname: Tuomilehto – volume: 43 start-page: 1093 year: 2000 end-page: 1098 ident: CR9 article-title: Use of cod-liver oil during pregnancy associated with lower risk of type 1 diabetes in the offspring publication-title: Diabetologia doi: 10.1007/s001250051499 contributor: fullname: Joner – volume: 358 start-page: 1500 issue: 9292 year: 2001 end-page: 1503 ident: CR5 article-title: Intake of vitamin D and risk of type 1 diabetes: a birth–cohort study publication-title: Lancet doi: 10.1016/S0140-6736(01)06580-1 contributor: fullname: Virtanen – volume: 45 start-page: 119 issue: 1 year: 2009 end-page: 124 ident: CR3 article-title: Vitamin D status and common risk factors for bone fragility as determinants of quantitative ultrasound variables in a nationally representative population sample publication-title: Bone doi: 10.1016/j.bone.2009.03.659 contributor: fullname: Mäki – volume: 84 start-page: 18 year: 2006 end-page: 28 ident: CR13 article-title: Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes publication-title: Am J Clin Nutr contributor: fullname: Dawson-Hughes – volume: 95 start-page: 1749 issue: 4 year: 2010 end-page: 1757 ident: CR15 article-title: Maternal vitamin D status determines bone variables in the newborn publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2009-1391 contributor: fullname: Hytinantti – volume: 12 start-page: 737 issue: 9 year: 2010 end-page: 743 ident: CR1 article-title: Vitamin D and increasing incidence of type 1 diabetes—evidence for an association? publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2010.01211.x contributor: fullname: Hyppönen – year: 2011 ident: CR12 publication-title: Dietary reference intakes for calcium and vitamin D – volume: 8 start-page: 11 issue: 1 year: 2007 end-page: 14 ident: CR7 article-title: Vitamin D supplementation and diabetes-related autoimmunity in the ABIS study publication-title: Pediatr Diabetes doi: 10.1111/j.1399-5448.2006.00223.x contributor: fullname: Ludvigsson – volume-title: Nordic nutrition recommendations 2004. Integrating nutrition and physical activity year: 2004 ident: 2458_CR11 contributor: fullname: Nordic Council of Ministers – volume: 45 start-page: 119 issue: 1 year: 2009 ident: 2458_CR3 publication-title: Bone doi: 10.1016/j.bone.2009.03.659 contributor: fullname: M Kauppi – volume: 8 start-page: 11 issue: 1 year: 2007 ident: 2458_CR7 publication-title: Pediatr Diabetes doi: 10.1111/j.1399-5448.2006.00223.x contributor: fullname: HK Brekke – volume: 95 start-page: 1749 issue: 4 year: 2010 ident: 2458_CR15 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2009-1391 contributor: fullname: HT Viljakainen – volume: 12 start-page: 737 issue: 9 year: 2010 ident: 2458_CR1 publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2010.01211.x contributor: fullname: E Hyppönen – volume: 371 start-page: 1777 issue: 9626 year: 2008 ident: 2458_CR2 publication-title: Lancet doi: 10.1016/S0140-6736(08)60765-5 contributor: fullname: V Harjutsalo – volume: 53 start-page: 1599 issue: 8 year: 2010 ident: 2458_CR10 publication-title: Diabetologia doi: 10.1007/s00125-010-1734-8 contributor: fullname: L Marjamäki – volume: 84 start-page: 18 year: 2006 ident: 2458_CR13 publication-title: Am J Clin Nutr doi: 10.1093/ajcn/84.1.18 contributor: fullname: HA Bischoff-Ferrari – volume-title: Dietary reference intakes for calcium and vitamin D year: 2011 ident: 2458_CR12 contributor: fullname: Institute of Medicine, Food and Nutrition Board – volume: 42 start-page: 51 year: 1999 ident: 2458_CR4 publication-title: Diabetologia doi: 10.1007/s001250051112 contributor: fullname: EURODIAB Substudy 2 Study Group – volume: 54 start-page: 2779 issue: 11 year: 2011 ident: 2458_CR8 publication-title: Diabetologia doi: 10.1007/s00125-011-2278-2 contributor: fullname: M Simpson – volume: 78 start-page: 1128 issue: 6 year: 2003 ident: 2458_CR6 publication-title: Am J Clin Nutr doi: 10.1093/ajcn/78.6.1128 contributor: fullname: LC Stene – volume: 358 start-page: 1500 issue: 9292 year: 2001 ident: 2458_CR5 publication-title: Lancet doi: 10.1016/S0140-6736(01)06580-1 contributor: fullname: E Hyppönen – volume: 43 start-page: 1093 year: 2000 ident: 2458_CR9 publication-title: Diabetologia doi: 10.1007/s001250051499 contributor: fullname: LC Stene – volume: 35 start-page: 70 year: 1992 ident: 2458_CR14 publication-title: Diabetologia doi: 10.1007/BF00400854 contributor: fullname: J Tuomilehto |
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Vitamin D deficiency during the fetal period or infancy is one of the suggested environmental factors for type 1 diabetes and for its... Vitamin D deficiency during the fetal period or infancy is one of the suggested environmental factors for type 1 diabetes and for its increasing incidence. To... |
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SubjectTerms | Adult Biological and medical sciences Case-Control Studies Child Child, Preschool Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - epidemiology Diabetes. Impaired glucose tolerance Dietary supplements Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Health care Human Physiology Humans Hypotheses Infant Internal Medicine Medical sciences Medicine Medicine & Public Health Metabolic Diseases Mothers Pregnancy Pregnancy - blood Pregnancy Trimester, First - blood Risk Short Communication Siblings Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - epidemiology Vitamin deficiency Womens health |
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Title | Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring |
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