Increased plasma TACE activity in subjects with mild cognitive impairment and patients with Alzheimer's disease

• Published in: Journal of Alzheimer's disease Vol. 41; no. 3; p. 877
• Main Authors: Sun, Qiying, Hampel, Harald, Blennow, Kaj, Lista, Simone, Levey, Allan, Tang, Beisha, Li, Rena, Shen, Yong
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2014
• Subjects: ADAM Proteins - blood; ADAM17 Protein; Aged; Alzheimer Disease - blood; Alzheimer Disease - cerebrospinal fluid; Amyloid beta-Peptides - cerebrospinal fluid; Case-Control Studies; Chi-Square Distribution; Cognitive Dysfunction - blood; Enzyme-Linked Immunosorbent Assay; Female; Humans; Linear Models; Male; Mental Status Schedule; Middle Aged; Peptide Fragments - cerebrospinal fluid; tau Proteins - cerebrospinal fluid; tumor necrosis factor converting enzyme; mild cognitive impairment; biomarker; plasma; Alzheimer's disease

Evidence suggests that the tumor necrosis factor receptor (TNFR)-signaling pathway contributes to the pathogenesis of Alzheimer's disease (AD). TNF-α converting enzyme (TACE/ADAM-17) can cleave both pro-TNF-α and TNF receptors. Recently, we have shown that TACE activity in the cerebrospinal flu...