GABA Concentration Is Reduced in Visual Cortex in Schizophrenia and Correlates with Orientation-Specific Surround Suppression

• Published in: The Journal of neuroscience Vol. 30; no. 10; pp. 3777 - 3781
• Main Authors: Yoon, Jong H, Maddock, Richard J, Rokem, Ariel, Silver, Michael A, Minzenberg, Michael J, Ragland, J. Daniel, Carter, Cameron S
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 10.03.2010; Society for Neuroscience
• Subjects: Adolescent; Adult; Brief Communications; Female; gamma-Aminobutyric Acid - analysis; gamma-Aminobutyric Acid - deficiency; gamma-Aminobutyric Acid - metabolism; Humans; Male; Orientation - physiology; Photic Stimulation - methods; Schizophrenia - metabolism; Schizophrenia - physiopathology; Synaptic Transmission - physiology; Visual Cortex - chemistry; Visual Cortex - metabolism; Young Adult

The neural mechanisms underlying cognitive deficits in schizophrenia remain essentially unknown. The GABA hypothesis proposes that reduced neuronal GABA concentration and neurotransmission results in cognitive impairments in schizophrenia. However, few in vivo studies have directly examined this hyp...