Photochemical Modification of the Extracellular Matrix to Alter the Vascular Remodeling Process

• Published in: Journal of functional biomaterials Vol. 14; no. 12; p. 566
• Main Authors: Anderson, Blake, Blair, Dylan, Huff, Kenji, Wisniewski, John, Warner, Kevin S, Kauser, Katalin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2023
• Subjects: Amino acids; bio-scaffold; Blood circulation disorders; Blood vessels; Carotid arteries; Carotid artery; Cell culture; Cell survival; Chemical bonds; Collagen; Collagenase; Covalent bonds; Degradation; Digital imaging; Dimers; Drug dosages; Elastase; Elastin; Extracellular matrix; Fibers; Fistula; Health aspects; Hemodynamics; Image analysis; Image processing; Light; Photochemicals; photosensitized protein crosslinking; Physiology; Proteins; Scaffolding; Segments; Therapeutic applications; tissue remodeling; vascular disease; Vascular diseases; vascular remodeling; Veins & arteries; United States > US; Germany; vascular disease; natural vascular scaffolding; bio-scaffold; tissue remodeling; vascular remodeling; extracellular matrix; photosensitized protein crosslinking

Therapeutic interventions for vascular diseases aim at achieving long-term patency by controlling vascular remodeling. The extracellular matrix (ECM) of the vessel wall plays a crucial role in regulating this process. This study introduces a novel photochemical treatment known as Natural Vascular Sc...