Dynamic micro- and macrovascular remodeling in coronary circulation of obese Ossabaw pigs with metabolic syndrome

• Published in: Journal of applied physiology (1985) Vol. 113; no. 7; pp. 1128 - 1140
• Main Authors: Trask, Aaron J, Katz, Paige S, Kelly, Amy P, Galantowicz, Maarten L, Cismowski, Mary J, West, T Aaron, Neeb, Zachary P, Berwick, Zachary C, Goodwill, Adam G, Alloosh, Mouhamad, Tune, Johnathan D, Sturek, Michael, Lucchesi, Pamela A
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.10.2012
• Subjects: Animals; Blood Flow Velocity - physiology; Cardiovascular disease; Collagen - metabolism; Coronary Circulation - physiology; Coronary Vessels - metabolism; Coronary Vessels - physiopathology; Diabetes; Elastin - metabolism; Hogs; Male; Metabolic syndrome; Metabolic Syndrome - metabolism; Metabolic Syndrome - physiopathology; Microvessels - metabolism; Microvessels - physiopathology; Obesity; Obesity - metabolism; Obesity - physiopathology; Physiology; Swine

Previous studies from our laboratory showed that coronary arterioles from type 2 diabetic mice undergo inward hypertrophic remodeling and reduced stiffness. The aim of the current study was to determine if coronary resistance microvessels (CRMs) in Ossabaw swine with metabolic syndrome (MetS) underg...