Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice

• Published in: Journal of virology Vol. 90; no. 4; pp. 2142 - 2149
• Main Authors: Bi, Yuhai, Xiao, Haixia, Chen, Quanjiao, Wu, Yan, Fu, Lifeng, Quan, Chuansong, Wong, Gary, Liu, Jun, Haywood, Joel, Liu, Yingxia, Zhou, Boping, Yan, Jinghua, Liu, Wenjun, Gao, George F.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 15.02.2016
• Subjects: Animals; Body Weight; Cytokines - analysis; Histocytochemistry; Influenza A Virus, H7N9 Subtype - genetics; Influenza A Virus, H7N9 Subtype - pathogenicity; Influenza virus; Lung - pathology; Lung - virology; Mice, Inbred BALB C; Neuraminidase - genetics; Orthomyxoviridae Infections - pathology; Orthomyxoviridae Infections - virology; Pathogenesis and Immunity; Sequence Deletion; Viral Load; Viral Proteins - genetics; Virulence; Virulence Factors - genetics

The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or re...