Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice

The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or re...

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Published inJournal of virology Vol. 90; no. 4; pp. 2142 - 2149
Main Authors Bi, Yuhai, Xiao, Haixia, Chen, Quanjiao, Wu, Yan, Fu, Lifeng, Quan, Chuansong, Wong, Gary, Liu, Jun, Haywood, Joel, Liu, Yingxia, Zhou, Boping, Yan, Jinghua, Liu, Wenjun, Gao, George F.
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 15.02.2016
Subjects
Animals
Body Weight
Cytokines - analysis
Histocytochemistry
Influenza A Virus, H7N9 Subtype - genetics
Influenza A Virus, H7N9 Subtype - pathogenicity
Influenza virus
Lung - pathology
Lung - virology
Mice, Inbred BALB C
Neuraminidase - genetics
Orthomyxoviridae Infections - pathology
Orthomyxoviridae Infections - virology
Pathogenesis and Immunity
Sequence Deletion
Viral Load
Viral Proteins - genetics
Virulence
Virulence Factors - genetics
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Abstract The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to that of a virus with a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19- to 20-amino-acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 stalk length does.
AbstractList The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to that of a virus with a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19- to 20-amino-acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 stalk length does.
The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to that of a virus with a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19- to 20-amino-acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 stalk length does.The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to that of a virus with a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19- to 20-amino-acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 stalk length does.
The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to that of a virus with a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19- to 20-amino-acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 stalk length does.
Author Zhou, Boping
Liu, Yingxia
Fu, Lifeng
Quan, Chuansong
Xiao, Haixia
Chen, Quanjiao
Liu, Wenjun
Bi, Yuhai
Haywood, Joel
Gao, George F.
Wu, Yan
Wong, Gary
Yan, Jinghua
Liu, Jun
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  surname: Bi
  fullname: Bi, Yuhai
  organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China, Center for Influenza Research and Early Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China
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  givenname: Haixia
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  organization: Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, Center for Influenza Research and Early Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China
– sequence: 3
  givenname: Quanjiao
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  organization: CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Hubei, China, Center for Influenza Research and Early Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China
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  organization: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China
– sequence: 7
  givenname: Gary
  surname: Wong
  fullname: Wong, Gary
  organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
– sequence: 8
  givenname: Jun
  surname: Liu
  fullname: Liu, Jun
  organization: Center for Influenza Research and Early Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China
– sequence: 9
  givenname: Joel
  surname: Haywood
  fullname: Haywood, Joel
  organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
– sequence: 10
  givenname: Yingxia
  surname: Liu
  fullname: Liu, Yingxia
  organization: Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China
– sequence: 11
  givenname: Boping
  surname: Zhou
  fullname: Zhou, Boping
  organization: Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China
– sequence: 12
  givenname: Jinghua
  surname: Yan
  fullname: Yan, Jinghua
  organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
– sequence: 13
  givenname: Wenjun
  surname: Liu
  fullname: Liu, Wenjun
  organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Center for Influenza Research and Early Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China
– sequence: 14
  givenname: George F.
  surname: Gao
  fullname: Gao, George F.
  organization: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen, China, Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China, Center for Influenza Research and Early Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China
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DocumentTitleAlternate Roles of the NA Stalk in H7N9 Pathogenesis
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Citation Bi Y, Xiao H, Chen Q, Wu Y, Fu L, Quan C, Wong G, Liu J, Haywood J, Liu Y, Zhou B, Yan J, Liu W, Gao GF. 2016. Changes in the length of the neuraminidase stalk region impact H7N9 virulence in mice. J Virol 90:2142–2149. doi:10.1128/JVI.02553-15.
Y.B., H.X., and Q.C. contributed equally to this work.
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Snippet The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological...
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SubjectTerms Animals
Body Weight
Cytokines - analysis
Histocytochemistry
Influenza A Virus, H7N9 Subtype - genetics
Influenza A Virus, H7N9 Subtype - pathogenicity
Influenza virus
Lung - pathology
Lung - virology
Mice, Inbred BALB C
Neuraminidase - genetics
Orthomyxoviridae Infections - pathology
Orthomyxoviridae Infections - virology
Pathogenesis and Immunity
Sequence Deletion
Viral Load
Viral Proteins - genetics
Virulence
Virulence Factors - genetics
Title Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice
URI https://www.ncbi.nlm.nih.gov/pubmed/26656694
https://www.proquest.com/docview/1761465713
https://www.proquest.com/docview/1768570236
https://pubmed.ncbi.nlm.nih.gov/PMC4734013
Volume 90
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