Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice

The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or re...

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Published inJournal of virology Vol. 90; no. 4; pp. 2142 - 2149
Main Authors Bi, Yuhai, Xiao, Haixia, Chen, Quanjiao, Wu, Yan, Fu, Lifeng, Quan, Chuansong, Wong, Gary, Liu, Jun, Haywood, Joel, Liu, Yingxia, Zhou, Boping, Yan, Jinghua, Liu, Wenjun, Gao, George F.
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 15.02.2016
Subjects
Animals
Body Weight
Cytokines - analysis
Histocytochemistry
Influenza A Virus, H7N9 Subtype - genetics
Influenza A Virus, H7N9 Subtype - pathogenicity
Influenza virus
Lung - pathology
Lung - virology
Mice, Inbred BALB C
Neuraminidase - genetics
Orthomyxoviridae Infections - pathology
Orthomyxoviridae Infections - virology
Pathogenesis and Immunity
Sequence Deletion
Viral Load
Viral Proteins - genetics
Virulence
Virulence Factors - genetics
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Summary:The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to that of a virus with a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19- to 20-amino-acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 stalk length does.
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Citation Bi Y, Xiao H, Chen Q, Wu Y, Fu L, Quan C, Wong G, Liu J, Haywood J, Liu Y, Zhou B, Yan J, Liu W, Gao GF. 2016. Changes in the length of the neuraminidase stalk region impact H7N9 virulence in mice. J Virol 90:2142–2149. doi:10.1128/JVI.02553-15.
Y.B., H.X., and Q.C. contributed equally to this work.
ISSN:0022-538X
1098-5514
1098-5514
DOI:10.1128/JVI.02553-15