3D printing of biomimetic multi-layered GelMA/nHA scaffold for osteochondral defect repair
Currently, osteochondral defects frequently cause limited motion and impaired function of the joint, leading to serious healthcare problems, and it is still very challenging to realize the simultaneous regeneration of subchondral bone with cartilage. In the current study, we designed a tri-layered s...
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| Published in | Materials & design Vol. 171; no. C; p. 107708 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United Kingdom
Elsevier Ltd
05.06.2019
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Currently, osteochondral defects frequently cause limited motion and impaired function of the joint, leading to serious healthcare problems, and it is still very challenging to realize the simultaneous regeneration of subchondral bone with cartilage. In the current study, we designed a tri-layered scaffold and fabricated it using the extrusion-based multi-nozzle 3D printing technology. The bioinks used for 3D printing included a 15% methacrylated gelatin (GelMA) hydrogel for cartilage on top layer, a combination of 20% GelMA and 3% nanohydroxyapatite (nHA) (20/3% GelMA/nHA) hydrogel for interfacial layer, and a 30/3% GelMA/nHA hydrogel for subchondral bone at bottom layer. The water absorption capacity, biodegradation, and mechanical properties of hydrogels and scaffolds were characterized, and in vitro assay with bone marrow mesenchymal stem cells (BMSCs) was performed to indicate the biocompatibility of scaffolds. Based on the results of in vivo repair of rabbit osteochondral defect, the neo-tissues in defects integrated better with the surrounding tissues, the joint surface of the defects was smoother, and more cartilage-specific extracellular matrix and collagen type II were observed using the tri-layered scaffolds. This study not only provides a potential manufacturing method for multi-layered scaffolds, but also is helpful for understanding the regeneration mechanism of cartilage-subchondral bone.
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•A functionally graded osteochondral scaffold was manufactured using GelMA/nHA hydrogels by extrusion-based 3D printing•The scaffold manufacturing process was simple and efficient without additional postprocess•The scaffolds have appropriate swelling ratio, biodegradation rate, mechanical properties, and excellent biocompatibility•The tri-layered GelMA/nHA scaffolds showed promising in vivo results of rabbit osteochondral defect repair |
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| AbstractList | Currently, osteochondral defects frequently cause limited motion and impaired function of the joint, leading to serious healthcare problems, and it is still very challenging to realize the simultaneous regeneration of subchondral bone with cartilage. In the current study, we designed a tri-layered scaffold and fabricated it using the extrusion-based multi-nozzle 3D printing technology. The bioinks used for 3D printing included a 15% methacrylated gelatin (GelMA) hydrogel for cartilage on top layer, a combination of 20% GelMA and 3% nanohydroxyapatite (nHA) (20/3% GelMA/nHA) hydrogel for interfacial layer, and a 30/3% GelMA/nHA hydrogel for subchondral bone at bottom layer. The water absorption capacity, biodegradation, and mechanical properties of hydrogels and scaffolds were characterized, and in vitro assay with bone marrow mesenchymal stem cells (BMSCs) was performed to indicate the biocompatibility of scaffolds. Based on the results of in vivo repair of rabbit osteochondral defect, the neo-tissues in defects integrated better with the surrounding tissues, the joint surface of the defects was smoother, and more cartilage-specific extracellular matrix and collagen type II were observed using the tri-layered scaffolds. This study not only provides a potential manufacturing method for multi-layered scaffolds, but also is helpful for understanding the regeneration mechanism of cartilage-subchondral bone.
[Display omitted]
•A functionally graded osteochondral scaffold was manufactured using GelMA/nHA hydrogels by extrusion-based 3D printing•The scaffold manufacturing process was simple and efficient without additional postprocess•The scaffolds have appropriate swelling ratio, biodegradation rate, mechanical properties, and excellent biocompatibility•The tri-layered GelMA/nHA scaffolds showed promising in vivo results of rabbit osteochondral defect repair Currently, osteochondral defects frequently cause limited motion and impaired function of the joint, leading to serious healthcare problems, and it is still very challenging to realize the simultaneous regeneration of subchondral bone with cartilage. In the current study, we designed a tri-layered scaffold and fabricated it using the extrusion-based multi-nozzle 3D printing technology. The bioinks used for 3D printing included a 15% methacrylated gelatin (GelMA) hydrogel for cartilage on top layer, a combination of 20% GelMA and 3% nanohydroxyapatite (nHA) (20/3% GelMA/nHA) hydrogel for interfacial layer, and a 30/3% GelMA/nHA hydrogel for subchondral bone at bottom layer. The water absorption capacity, biodegradation, and mechanical properties of hydrogels and scaffolds were characterized, and in vitro assay with bone marrow mesenchymal stem cells (BMSCs) was performed to indicate the biocompatibility of scaffolds. Based on the results of in vivo repair of rabbit osteochondral defect, the neo-tissues in defects integrated better with the surrounding tissues, the joint surface of the defects was smoother, and more cartilage-specific extracellular matrix and collagen type II were observed using the tri-layered scaffolds. This study not only provides a potential manufacturing method for multi-layered scaffolds, but also is helpful for understanding the regeneration mechanism of cartilage-subchondral bone. Keywords: 3D printing, Scaffold, Methacrylated gelatin (GelMA), Osteochondral defect, Cartilage repair |
| ArticleNumber | 107708 |
| Author | Yan, Mengling Suo, Hairui Liu, Jingyi Li, Liang Fu, Jianzhong Yin, Jun |
| Author_xml | – sequence: 1 givenname: Jingyi surname: Liu fullname: Liu, Jingyi organization: The State Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310028, China – sequence: 2 givenname: Liang surname: Li fullname: Li, Liang organization: Department of Orthopedics, No. 906 Hospital of People's Liberation Army, Ningbo 315040, China – sequence: 3 givenname: Hairui surname: Suo fullname: Suo, Hairui organization: College of Automation, Hangzhou Dianzi University, Hangzhou 310018, China – sequence: 4 givenname: Mengling surname: Yan fullname: Yan, Mengling organization: The State Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310028, China – sequence: 5 givenname: Jun orcidid: 0000-0002-1937-6812 surname: Yin fullname: Yin, Jun email: junyin@zju.edu.cn organization: The State Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310028, China – sequence: 6 givenname: Jianzhong surname: Fu fullname: Fu, Jianzhong email: fjz@zju.edu.cn organization: The State Key Laboratory of Fluid Power and Mechatronic Systems, College of Mechanical Engineering, Zhejiang University, Hangzhou 310028, China |
| BackLink | https://www.osti.gov/biblio/1547619$$D View this record in Osti.gov |
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| Keywords | Cartilage repair Scaffold 3D printing Osteochondral defect Methacrylated gelatin (GelMA) |
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| SubjectTerms | 3D printing Cartilage repair Methacrylated gelatin (GelMA) Osteochondral defect Scaffold |
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| Title | 3D printing of biomimetic multi-layered GelMA/nHA scaffold for osteochondral defect repair |
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