Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism

• Published in: Toxicology and applied pharmacology Vol. 244; no. 3; pp. 291 - 299
• Main Authors: Meng, Dan, Wang, Xin, Chang, Qingshan, Hitron, Andrew, Zhang, Zhuo, Xu, Mei, Chen, Gang, Luo, Jia, Jiang, Binghua, Fang, Jing, Shi, Xianglin
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.05.2010; Elsevier
• Subjects: 60 APPLIED LIFE SCIENCES; ALKALI METALS; AMINO ACIDS; ANGIOGENESIS; Angiogenesis Inducing Agents - toxicity; ANIMALS; ARSENIC; Arsenic - toxicity; Arsenites - toxicity; Bach1; Basic-Leucine Zipper Transcription Factors - metabolism; BIOASSAY; Biological and medical sciences; CARBOXYLIC ACIDS; Carcinogenesis, carcinogens and anticarcinogens; CARDIOVASCULAR DISEASES; Cell Movement - drug effects; Cells, Cultured; Chemical agents; Chemical and industrial products toxicology. Toxic occupational diseases; CHROMATIN; CYSTEINE; DISEASES; DNA; ELEMENTS; Endothelial; Endothelial Cells - drug effects; Endothelial Cells - metabolism; ENZYME IMMUNOASSAY; ENZYMES; Fanconi Anemia Complementation Group Proteins - metabolism; Gene Expression Regulation - drug effects; GENES; GROWTH FACTORS; HEME; Heme oxygenase 1; Heme Oxygenase-1 - metabolism; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; Humans; IMMUNOASSAY; IN VITRO; LUCIFERASE; MALES; MAMMALS; MAN; MAP Kinase Kinase 4 - metabolism; Medical sciences; MEN; MESSENGER-RNA; METALS; Metals and various inorganic compounds; Microvessels - drug effects; Microvessels - metabolism; MITOGENS; MUTAGENESIS; Neovascularization, Physiologic - drug effects; NF-E2-Related Factor 2 - metabolism; Nrf2; NUCLEIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; OXIDASES; OXIDOREDUCTASES; OXYGENASES; p38 Mitogen-Activated Protein Kinases - metabolism; PATHOGENESIS; Phosphatidylinositol 3-Kinases - metabolism; PIGMENTS; PORPHYRINS; PRIMATES; Protein Kinase C - metabolism; PROTEINS; Reactive Oxygen Species - metabolism; RNA; RNA, Messenger - metabolism; SEMIMETALS; SODIUM; THIOLS; Toxicology; Tumors; Vascular Endothelial Growth Factor A - metabolism; VERTEBRATES; Angiogenesis; Bach1; Heme oxygenase 1; Maf; MARE; Arsenic; Nrf2; HMVECs; VEGF; Endothelial; HO-1; ChIP; Endothelial cell; Enzyme; Heme oxygenase (decyclizing); In vitro; Endothelium; Carcinogen; Heat shock protein; Oxidoreductases; Neovascularization; Mechanism of action

Angiogenesis and vessel remodeling are fundamental to the pathogenesis of a number of diseases caused by environmental arsenic exposure, including tumorigenesis and cardiovascular diseases. Arsenic (AsIII) has been shown to stimulate angiogenesis and vascular remodeling in vivo. However, the exact m...