Exaggerated auditory startle responses in multiple system atrophy: a comparative study of parkinson and cerebellar subtypes

• Published in: Clinical neurophysiology Vol. 114; no. 3; pp. 541 - 547
• Main Authors: Kofler, Markus, Müller, Jörg, Seppi, Klaus, Wenning, Gregor K
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.03.2003; Elsevier Science
• Subjects: Acoustic Stimulation; Aged; Auditory startle reaction; Biological and medical sciences; Brain Stem - physiology; Brainstem reflex; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Facial Muscles - physiology; Female; Humans; Male; Medical sciences; Middle Aged; MSA-C; MSA-P; Multiple system atrophy; Neck Muscles - physiology; Neurology; Olivopontocerebellar Atrophies - diagnosis; Olivopontocerebellar Atrophies - physiopathology; Parkinsonian Disorders - diagnosis; Parkinsonian Disorders - physiopathology; Reaction Time - physiology; Reflex - physiology; Reflex, Startle - physiology; Multiple system atrophy; MSA-C; Brainstem reflex; Auditory startle reaction; MSA-P; Human; Nervous system diseases; Pathophysiology; Brain stem; Startle reflex; Cerebral disorder; Electrodiagnosis; Acoustic stimulus; Central nervous system disease; Degenerative disease; Subtype; Comparative study; Brain (vertebrata)

Objective: Auditory startle responses (ASRs) have recently been reported to be exaggerated in cranial and peripheral nerve supplied muscles of patients with multiple system atrophy (MSA). ASRs displayed increased probability, amplitude and duration, shorter onset latency, and reduced habituation in...