Changes in BQCA Allosteric Modulation of [3H]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 41; no. 6; pp. 1620 - 1628
• Main Authors: Dean, Brian, Hopper, Shaun, Conn, P Jeffrey, Scarr, Elizabeth
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.05.2016
• Subjects: Allosteric Regulation - physiology; Antipsychotics; Cations, Divalent - pharmacology; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Cerebral Cortex - physiopathology; Drug dosages; Female; Humans; Hypotheses; Male; Mental health; Middle Aged; N-Methylscopolamine - metabolism; Neurosciences; Original; Pharmacology; Pirenzepine - pharmacology; Psychotropic drugs; Quinolines - pharmacology; Receptor, Muscarinic M1; Receptors, Muscarinic - drug effects; Receptors, Muscarinic - physiology; Schizophrenia; Schizophrenia - metabolism; Australia

Stimulation of the cortical muscarinic M1 receptor (CHRM1) is proposed as a treatment for schizophrenia, a hypothesis testable using CHRM1 allosteric modulators. Allosteric modulators have been shown to change the activity of CHRMs using cloned human CHRMs and CHRM knockout mice but not human CNS, a...