Iron chelators as antimalarial agents: in vitro activity of dicatecholate against Plasmodium falciparum

• Published in: Journal of antimicrobial chemotherapy Vol. 50; no. 2; pp. 177 - 187
• Main Authors: Pradines, B., Rolain, J. M., Ramiandrasoa, F., Fusai, T., Mosnier, J., Rogier, C., Daries, W., Baret, E., Kunesch, G., Le Bras, J., Parzy, D.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.08.2002; Oxford Publishing Limited (England)
• Subjects: Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimalarials - chemistry; Antimalarials - pharmacology; Antiparasitic agents; Biological and medical sciences; Catechols - chemistry; Catechols - pharmacology; Cercopithecus aethiops; Cholates - chemistry; Cholates - pharmacology; Erythrocytes - drug effects; Iron Chelating Agents - chemistry; Iron Chelating Agents - pharmacology; Medical sciences; Pharmacology. Drug treatments; Plasmodium falciparum - drug effects; Plasmodium falciparum - growth & development; Vero Cells; Protozoa; Antimalarial; Apicomplexa; Drug combination; Microorganism growth; Ascorbic acid; Toxicity; Iron II; Ferritin; Vitamin; In vitro; Biological activity; Plasmodium falciparum; Iron III; Structure activity relation; Parasiticid; Chelating agent; Drug interaction

The present study was undertaken to explore the antimalarial effect of a series of dicatecholate iron chelators. They may be made more or less lipophilic by increasing or reducing the length of the R substituent on the nitrogen. In vitro activity against the W2 and 3D7 clones of Plasmodium falciparu...