An in silico approach to unveil peptides from Acheta domesticus with potential bioactivity against hypertension, diabetes, cardiac and pulmonary fibrosis

• Published in: Food research international Vol. 169; p. 112847
• Main Authors: Teixeira, Carla S.S., Villa, Caterina, Sousa, Sérgio F., Costa, Joana, Ferreira, Isabel M.P.L.V.O., Mafra, Isabel
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Ltd 01.07.2023
• Subjects: Acheta domesticus; angiotensin I; Angiotensin-I converting enzyme; Anti-fibrosis; Anti-hypertensive; Antidiabetic; Bioactive peptides; bioactive properties; computer simulation; diabetes; digestion; Dipeptidyl peptidase 4; drugs; entomophagy; enzymes; European Union; food research; gastrointestinal system; human nutrition; hypertension; insects; probability; pulmonary fibrosis; species; Anti-fibrosis; Dipeptidyl peptidase 4; Anti-hypertensive; Acheta domesticus; Antidiabetic; Angiotensin-I converting enzyme; Bioactive peptides

[Display omitted] •In silico gastrointestinal digestion was applied to six A. domesticus proteins.•Five peptides were identified by molecular docking with high scores for two enzymes.•They showed potential to inhibit the DPP-4 and both catalytic domains of sACE.•New antidiabetic and anti-hypertensiv...